Stem Cell Research & Therapy is the major forum for translational research into stem cell therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into stem cell therapeutics and regenerative therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports.
- Rocky S Tuan, University of Pittsburgh School of Medicine
- Timothy O'Brien, National University of Ireland, Galway
Lewis and Suzuki review mesenchymal stem cell therapy for amyotrophic lateral sclerosis (ALS) including mechanisms of action, cell source and delivery, and translation from preclinical models into early-phase clinical trials.
Generation of neuronal-like networks from murine dental pulp stem cells supports the development of mouse models of autologous neural therapeutic transplantations for preclinical studies.
Human Wharton’s jelly-mesenchymal stem cells promote skin wound healing through paracrine signalling in a mouse model, and could potentially improve patient survival and quality of life.
Differentiating embryonic stem cells (ESCs) express increasing amounts of growth factors over time that are capable of stimulating mitogenic and motogenic activity of exogenous cell populations.
Friederike Schröter and James Adjaye review the role of the proteasome complex in the regulation of self-renewal, pluripotency and differentiation of both embryonic and induced pluripotent stem cells.
A proof-of-concept study shows that adipose-derived stem cells from the neonatal foreskin have therapeutic potential for congenital muscular dystrophy, as they can synthesize and excrete collagen VI.
Myocardial transfection of hypoxia-inducible 1 factor-1α (HIF-1α) and co-transplantation of mesenchymal stem cells (MSCs) enhance cardiac repair after myocardial infarction in rats, indicating the potential of combination treatment for patients.
The recent establishment of mammalian haploid embryonic stem cells offers a new tool for genetic studies, and insights regarding genome ploidy maintenance and genomic imprinting; Ling Shuai and Qi Zhou review their characteristics and potential applications.
Ronald Li and colleagues review the biological, physical and topographical cues associated with the development of cardiomyocytes, and how these insights can be applied to facilitate maturation of human pluripotent stem cell-derived cardiomyocytes.
Latest free review
The following review has recently become free to access:
Janna V Serbo, Sharon GerechtStem Cell Research & Therapy 2013, 4:8
(24 January 2013)
Volume 4 Suppl 1 (20 December 2013)
"Stem cells have enormous potential for alleviating suffering for many diseases which currently have no effective therapy. The field has progressed to the clinic and it is important that this pathway is underpinned by excellent science and rigorous standards of clinical research. The journal provides an important avenue of publication in translational aspects of stem cell therapy spanning preclinical studies, clinical research and commercialization."
Prof. Timothy O'Brien,
Stem Cell Research & Therapy
"The study of stem cells is one of the most exciting areas of contemporary biomedical research. We believe that Stem Cell Research & Therapy will act as a highly active forum for both basic and translational research into stem cell biology and therapies. Specifically, by developing this forum for cutting edge research, we hope that Stem Cell Research & Therapy will play a significant role in bringing together the critical information to synergize stem cell science with stem cell therapies."
Dr. Rocky S Tuan
Stem Cell Research & Therapy