Stem Cell Research & Therapy is the major forum for translational research into stem cell therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into stem cell therapeutics and regenerative therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports.
- Rocky S Tuan, University of Pittsburgh School of Medicine
- Timothy O'Brien, National University of Ireland, Galway
Maintaining CD70 expression may enable continued immune escape in neural stem cell (NSC) transplantation as interaction between CD70 on NSCs and CD27 on T cells initiates NSC-induced CD4+ T cell apoptosis.
Dental pulp- and amniotic fluid-derived stem cells seeded into collagen scaffolds repair large cranial bone defects in a rat model and are involved in vascularization of the implant.
Copolymer scaffolds can be prevascularized with endothelial cells (EC) and mesenchymal stem cells (MSC); seeding of MSC with or without EC increases the osteogenic potential of tissue-engineered constructs.
Adult neural stem cells extracted from the olfactory bulb of diabetic rats can be cultured in vitro and show similar gene expression profiles to hippocampal neural stem cells during diabetes progression.
Human first-trimester decidua side population cells can differentiate into endothelial cells and form tube-like structures in vitro and may induce vasculogenesis in vivo in the ischemic limb nude mouse model.
Higher expression levels of the hematopoiesis-related genes SALL4 and BMI-1 in placental tissue compared with umbilical cord blood suggest it might be a good source for expansion of hematopoietic progenitor cells (HPCs).
Intravenous administration of cryopreserved allogeneic adipose-derived mesenchymal stem cells in cats with chronic kidney disease resulted in significant adverse effects and no clinical improvement.
Celia Gomes comments on research showing human mesenchymal stem cells (MSCs) slow tumor growth in established murine tumors, whereas MSC administration appears to increase growth in newly formed tumors.
Injection of human mesenchymal stem cells into established tumors in mice slowed tumor growth, and this effect appeared to be due to changes in tumor angiogenesis.
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Latest free review
The following review has recently become free to access:
Ian Wimpenny, Hareklea Markides, Alicia J El HajStem Cell Research & Therapy 2012, 3:13
(19 April 2012)
"Stem cells have enormous potential for alleviating suffering for many diseases which currently have no effective therapy. The field has progressed to the clinic and it is important that this pathway is underpinned by excellent science and rigorous standards of clinical research. The journal provides an important avenue of publication in translational aspects of stem cell therapy spanning preclinical studies, clinical research and commercialization."
Prof. Timothy O'Brien,
Stem Cell Research & Therapy
"The study of stem cells is one of the most exciting areas of contemporary biomedical research. We believe that Stem Cell Research & Therapy will act as a highly active forum for both basic and translational research into stem cell biology and therapies. Specifically, by developing this forum for cutting edge research, we hope that Stem Cell Research & Therapy will play a significant role in bringing together the critical information to synergize stem cell science with stem cell therapies."
Dr. Rocky S Tuan
Stem Cell Research & Therapy