Stem Cell Research & Therapy is the major forum for translational research into stem cell therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into stem cell therapeutics and regenerative therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports.
- Rocky S Tuan, University of Pittsburgh School of Medicine
- Timothy O'Brien, National University of Ireland, Galway
Cynthia Coleman and colleagues review recent advances in the identification, isolation, and mechanism of action of mesenchymal stem cells in bone fracture repair, and discuss their clinical implications.
Fetal placental mesenchymal stem cells (MSCs) express higher levels of CD200 and hepatocyte growth factor compared with maternal placental MSCs, and show increased potential for promoting angiogenesis and immunosuppression.
Pingpin Wei et al. review recent studies on cancer-like stem cells in nasopharyngeal carcinoma, including their isolation, characterisation and therapeutic approaches.
Sherry Wang and Jun Ren comment on recent research showing that inhibition of IP6Ks turns on Akt signaling, decreases apoptosis, and modulates the paracrine profile in mesenchymal stem cells.
Administration of adult bone marrow-derived stem cells appears to improve lung function, inflammatory response and hemodynamic changes in a sheep model of acute respiratory distress syndrome (ARDS).
Mutant lamin A occurrence and high shear stress correlate with a reduction in the level of mechanotransduction proteins in smooth muscle cells which may contribute to development of vasculopathy in progeria syndrome.
Dimitrios Zeugolis and colleagues discuss recent advances in stem cell carriers for tendon tissue engineering in preclinical models, including injectable carriers, tissue grafts and anisotropic scaffolds.
Dopaminergic cells and other functional neurons, which may be used to develop novel regenerative treatment strategies, can be generated from human cord blood-derived induced pluripotent stem cells (hCBiPSCs).
Human neural crest-derived stem cells can be successfully cultured in a clinical Good Manufacturing Practice-compliant culture bag system using human blood plasma-supplemented medium, suggesting its potential for clinical applications in regenerative medicine.
Latest free review
The following review has recently become free to access:
Nimalan Thavandiran, Sara S Nunes, Yun Xiao, Milica RadisicStem Cell Research & Therapy 2013, 4:14
(14 February 2013)
Volume 4 Suppl 1 (20 December 2013)
"Stem cells have enormous potential for alleviating suffering for many diseases which currently have no effective therapy. The field has progressed to the clinic and it is important that this pathway is underpinned by excellent science and rigorous standards of clinical research. The journal provides an important avenue of publication in translational aspects of stem cell therapy spanning preclinical studies, clinical research and commercialization."
Prof. Timothy O'Brien,
Stem Cell Research & Therapy
"The study of stem cells is one of the most exciting areas of contemporary biomedical research. We believe that Stem Cell Research & Therapy will act as a highly active forum for both basic and translational research into stem cell biology and therapies. Specifically, by developing this forum for cutting edge research, we hope that Stem Cell Research & Therapy will play a significant role in bringing together the critical information to synergize stem cell science with stem cell therapies."
Dr. Rocky S Tuan
Stem Cell Research & Therapy