Stem Cell Research & Therapy is the major forum for translational research into stem cell therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into stem cell therapeutics and regenerative therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports.
- Rocky S Tuan, University of Pittsburgh School of Medicine
- Timothy O'Brien, National University of Ireland, Galway
Cell retention and subsequent functional benefits via retrograde coronary infusion are significantly enhanced by magnetic targeting of mesenchymal stem cells in a rat model of myocardial infarction.
Progenitor cells from the swine buccal fat pad (BFP) have mesenchymal features and are capable of osteodifferentiation, indicating human BFP-adipose-derived stem cells may have clinical applications in dental tissue engineering.
After transduction with MYOD lentiviruses, human amniotic fluid stem cells (hAFS cells) are capable of myogenic differentiation in vitro, and muscle regeneration in a mouse model of muscle injury.
Culture in a rotating bioreactor allows the generation of large numbers of high-quality hepatocytes from mouse embryonic stem cells, and may be useful for generation of hepatocytes for cell transplantation and bioartificial liver development.
Jinhua Yu and Yao Li comment on recent research showing that mesenchymal stem cells can act on multiple myeloma cells via the Fas/FasL pathway, and its implications for therapy.
Pelosi and Sutherasan comment on recent research demonstrating the effects of bone marrow derived mononuclear transfusion may vary between models of sepsis-induced acute respiratory distress syndrome depending on the initial insult.
Michael Detamore comments on recent research exploring the potential of human umbilical cord mesenchymal stem cells for intervertebral disc regeneration and the use of an extracellular matrix-based strategy as opposed to growth factors.
Human fetal pancreatic progenitor cells can differentiate into insulin-producing cells and form islet-like structures in vitro, and are capable of secreting insulin to reduce hyperglycemia on transplantation into diabetic nude mice.
Marianne Verhaar and colleagues comment on the results of a recent clinical trial using allogeneic mesenchymal stromal cells (MSCs) to treat critical limb ischemia, one of the first such studies in humans.
Latest free review
The following review has recently become free to access:
Evelyn KF Yim, Michael P SheetzStem Cell Research & Therapy 2012, 3:41
(31 October 2012)
"Stem cells have enormous potential for alleviating suffering for many diseases which currently have no effective therapy. The field has progressed to the clinic and it is important that this pathway is underpinned by excellent science and rigorous standards of clinical research. The journal provides an important avenue of publication in translational aspects of stem cell therapy spanning preclinical studies, clinical research and commercialization."
Prof. Timothy O'Brien,
Stem Cell Research & Therapy
"The study of stem cells is one of the most exciting areas of contemporary biomedical research. We believe that Stem Cell Research & Therapy will act as a highly active forum for both basic and translational research into stem cell biology and therapies. Specifically, by developing this forum for cutting edge research, we hope that Stem Cell Research & Therapy will play a significant role in bringing together the critical information to synergize stem cell science with stem cell therapies."
Dr. Rocky S Tuan
Stem Cell Research & Therapy