Stem Cell Research & Therapy is the major forum for translational research into stem cell therapies. An international peer-reviewed journal, it publishes high quality open access research articles with a special emphasis on basic, translational and clinical research into stem cell therapeutics and regenerative therapies, including animal models and clinical trials. The journal also provides reviews, viewpoints, commentaries and reports.
- Rocky S Tuan, University of Pittsburgh School of Medicine
- Timothy O'Brien, National University of Ireland, Galway
The cardioregeneration capability of cardiomyocyte progenitor cells is improved by electric field stimulation; this could be used to modify cardiac progenitor cells towards a cardiogenic phenotype and incorporated into transdifferentiation protocols.
Although phenotypically identical, pericardial adipose tissue-derived stromal cells (ADSCs) in comparison to subcutaneous ADSCs were shown to exhibit potent differentiation towards cardiomyocytes and induced significant structural repair in the injured heart.
Corti and colleagues review the experimental approaches for differentiating human embryonic stem cells and human induced pluripotent stem cells towards functional motor neurons, and summarise their potential clinical applications.
Peritenon-derived and tendon proper progenitors respond uniquely in a regenerative model, highlighting the synergistic potential of including these progenitor populations in restorative tendon engineering strategies.
Diabetic mesenchymal stem cells derived from adipose tissue (ASCs) have impaired functional and therapeutic capacity due to their ability to establish a vascular network in vitro and in vivo.
A new fibrin sealant derived from snake venom shows potential as a three-dimensional scaffold for mesenchymal stem cells, maintaining cell survival without promoting differentiation.
James Byrne comments on recent research demonstrating that genetically modified neural stem cells can deliver disease-modifying therapeutic proteins throughout the brains of rodent models of Alzheimer’s disease.
Immortalized human adipose-derived stromal cells maintain most of their original mesenchymal features, in particular the capability to produce significant amounts of angiogenic factors, with potential advantages for laboratory research and regenerative medicine.
Specific gene markers which distinguish aging multipotent stromal cells (MSCs) grown in culture are identified through gene expression profiling using microarray technology.
Latest free review
The following review has recently become free to access:
Natasha Baker, Rocky S TuanStem Cell Research & Therapy 2013, 4:90 (30 July 2013)
"Stem cells have enormous potential for alleviating suffering for many diseases which currently have no effective therapy. The field has progressed to the clinic and it is important that this pathway is underpinned by excellent science and rigorous standards of clinical research. The journal provides an important avenue of publication in translational aspects of stem cell therapy spanning preclinical studies, clinical research and commercialization."
Prof. Timothy O'Brien,
Stem Cell Research & Therapy
"The study of stem cells is one of the most exciting areas of contemporary biomedical research. We believe that Stem Cell Research & Therapy will act as a highly active forum for both basic and translational research into stem cell biology and therapies. Specifically, by developing this forum for cutting edge research, we hope that Stem Cell Research & Therapy will play a significant role in bringing together the critical information to synergize stem cell science with stem cell therapies."
Dr. Rocky S Tuan
Stem Cell Research & Therapy