Stem Cell Research & Therapy

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		Review Strategies for enrichment and selection of stem cell-derived tissue precursors Harold S Bernstein, William C Hyun Stem Cell Research & Therapy 2012, 3:17 (10 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bernstein and Hyun review strategies used to direct tissue-specific differentiation of embryonic stem cells (ESCs), and methods for the identification and selection of tissue-specific precursors for scientific study and clinical use.
		Research The secretome of stem cells isolated from the adipose tissue and Wharton's jelly acts differently on central nervous system-derived cell populations Carlos A Ribeiro, Joana S Fraga, Mario Graos, Nuno M Neves, Rui L Reis, Jeffrey M Gimble, Nuno Sousa, Antonio J Salgado Stem Cell Research & Therapy 2012, 3:18 (2 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The secretome of human umbilical cord perivascular cells (HUPVCs) and adipose tissue-derived stem cells differ, with HUPVC conditioned media able to promote neuronal survival and differentiation without exogenous supplement.
		Editorial Stem Cell Research & Therapy in 2012 Philippa Locke, Rocky S Tuan, Timothy O'Brien Stem Cell Research & Therapy 2012, 3:16 (30 April 2012) Abstract \| Full text \| PDF \| PubMed
		Commentary Colonizing the heart from the epicardial side Nenad Bursac Stem Cell Research & Therapy 2012, 3:15 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nenad Bursac comments on recent research describing a distinct population of epicardium-derived mesenchymal stem cells residing in a perivascular niche of the heart with a broad multilineage potential, and considers future applications.
		Review Orthopaedic applications of nanoparticle-based stem cell therapies Ian Wimpenny, Hareklea Markides, Alicia J El Haj Stem Cell Research & Therapy 2012, 3:13 (19 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alicia El Haj and colleagues review recent research on the applications of iron-oxide-based magnetic nanoparticles to improve how stem cells are controlled, monitored and targeted to sites of repair.
		Research Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome Xiaoning Mou, Yuanbo Wu, Henghua Cao, Qingzhang Meng, Qihui Wang, Chengchao Sun, Shengshou Hu, Yue Ma, Hao Zhang Stem Cell Research & Therapy 2012, 3:14 (18 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The derivation of induced pluripotent stem cells (iPSCs) from two patients with different karyotypes of Down syndrome offers opportunities for disease modeling, drug discovery and potential future cell replacement therapies.
		Review Progress on stem cell research towards the treatment of Parkinson's disease Stuart AJ Gibson, Guo-Dong Gao, Katya McDonagh, Sanbing Shen Stem Cell Research & Therapy 2012, 3:11 (3 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sanbing Shen and colleagues provide an overview of recent progress towards a combined approach of drugs, cell replacement, and gene therapy to halt disease progression and improve treatment of Parkinson's disease.
		Research Production and validation of a good manufacturing practice grade human fibroblast line for supporting human embryonic stem cell derivation and culture Nilendran Prathalingam, Linda Ferguson, Lesley Young, Georg Lietz, Rachel Oldershaw, Lyn Healy, Albert Craig, Helen Lister, Rakesh Binaykia, Radhika Sheth, Alison Murdoch, Mary Herbert Stem Cell Research & Therapy 2012, 3:12 (28 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The human fibroblast line Ncl1Fed1A, produced in compliance with good manufacturing practice (GMP) standards, has been qualified for derivation and maintenance of human embryonic stem cells (hESCs).
		Review Dormancy in the stem cell niche Roberta Sottocornola, Cristina Lo Celso Stem Cell Research & Therapy 2012, 3:10 (19 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sottocornola and Lo Celso review recent findings on dormant hematopoietic stem cells, examining whether the mechanism of dormancy is common amongst regenerating tissues, and discuss implications for cancer therapy.
		Review Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells Tohru Sugawara, Koichiro Nishino, Akihiro Umezawa, Hidenori Akutsu Stem Cell Research & Therapy 2012, 3:8 (8 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hide Akutsu and colleagues review recent research on variation in induced pluripotent stem (iPS) cells, their ability to differentiate and the identity of the differentiated cells.
		Research Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells Adetola B Adesida, Aillette Mulet-Sierra, Nadr M Jomha Stem Cell Research & Therapy 2012, 3:9 (2 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hypoxia-mediated isolation and expansion increases the chondrogenic potential of bone marrow mesenchymal stromal cells (BMSCs) and may improve their clinical applications in cartilage repair.
		Review Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head Lars Rackwitz, Lars Eden, Stephan Reppenhagen, Johannes C Reichert, Franz Jakob, Heike Walles, Oliver Pullig, Rocky S Tuan, Maximilian Rudert, Ulrich Nöth Stem Cell Research & Therapy 2012, 3:7 (22 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ulrich Noth and colleagues review regenerative medicine approaches to treating avascular necrosis of the femoral head, a debilitating disease often leading to osteoarthritis and eventually hip replacement in young adults.
		Research Phenotypical and functional characteristics of mesenchymal stem cells from bone marrow: comparison of culture using different media supplemented with human platelet lysate or fetal bovine serum Nesrine Azouna, Faouzi Jenhani, Zohra Regaya, Lamia Berraeis, Tarek Othman, Elfi Ducrocq, Jorge Domenech Stem Cell Research & Therapy 2012, 3:6 (14 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells expanded in human platelet lysate supplemented media without fetal bovine serum (FBS) retain their phenotype and differentiation capacity, while an increased growth rate may allow for reduced culture time.
		Research Interleukin-1β and transforming growth factor-β cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells Lei Wang, Ziyan Liu, Sivasai Balivada, Tej Shrestha, Stefan Bossmann, Marla Pyle, Loretta Pappan, Jishu Shi, Deryl Troyer Stem Cell Research & Therapy 2012, 3:5 (10 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Glioma cells that fail to self-renew in standard conditions can gain this ability after exposure to IL-1β and TGF-β suggesting targeting glioma stem cell-promoting cytokines may increase the efficacy of glioma therapies.
		Commentary Stem cell-based therapy for α₁-antitrypsin deficiency S Tamir Rashid, David A Lomas Stem Cell Research & Therapy 2012, 3:4 (9 February 2012) Abstract \| Full text \| PDF \| PubMed
		Review The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms Sara Morando, Tiziana Vigo, Marianna Esposito, Simona Casazza, Giovanni Novi, Maria Principato, Roberto Furlan, Antonio Uccelli Stem Cell Research & Therapy 2012, 3:3 (26 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Many studies have demonstrated that mesenchymal stem cells are effective in the treatment of experimental autoimmune encephalomyelitis (EAE) and may have potential as a therapeutic option in multiple sclerosis.
		Review Bone marrow mononuclear cells and acute myocardial infarction Samer Arnous, Abdul Mozid, John Martin, Anthony Mathur Stem Cell Research & Therapy 2012, 3:2 (17 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The use of bone-marrow derived mononuclear cells in cardiac repair after acute myocardial infarction, a leading cause of death and disability, is reviewed by Anthony Mathur and colleagues.
		Commentary When one cell is enough Rhodri Ceredig Stem Cell Research & Therapy 2012, 3:1 (13 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rhodri Ceredig discusses a significant advance in our understanding of human hematopoiesis.
		Review Stem cell therapy for retinal diseases: update Rubens Siqueira Stem Cell Research & Therapy 2011, 2:50 (29 December 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients Reinhold J Medina, Desmond B Archer, Alan W Stitt Stem Cell Research & Therapy 2011, 2:47 (7 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation Tayaramma Thatava, Adam S Armstrong, Josep De Lamo, Ramakrishna Edukulla, Yulia Khan, Toshie Sakuma, Seiga Ohmine, Jamie L Sundsbak, Peter C Harris, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:48 (6 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Disease-specific induced pluripotent stem cells (iPSCs) have been generated from kidney transplant recipients, providing opportunities to study patient-specific disease pathogenesis in vitro and demonstrating potential for autologous kidney replacement therapy.
		Review Finding a niche: studies from the Drosophila ovary Susan Eliazer, Michael Buszczak Stem Cell Research & Therapy 2011, 2:45 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
		Review Uses of cardiomyocytes generated from induced pluripotent stem cells Tung-Ying Lu, Lei Yang Stem Cell Research & Therapy 2011, 2:44 (18 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells Seiga Ohmine, Allan B Dietz, Michael C Deeds, Katherine A Hartjes, David R Miller, Tayaramma Thatava, Toshie Sakuma, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:46 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hematopoietic progenitor cells and peripheral blood mononuclear cells could be ideal somatic cell sources for clinical-grade induced pluripotent stem cell (iPSC) derivation, allowing minimally invasive tissue procurement and rapid cellular reprogramming.
		Research MicroRNA profiling reveals age-dependent differential expression of nuclear factor κB and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells Amitabh C Pandey, Julie A Semon, Deepak Kaushal, Regina P O'Sullivan, Julie Glowacki, Jeffery M Gimble, Bruce A Bunnell Stem Cell Research & Therapy 2011, 2:49 (14 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Differential expression of microRNAs is an integral component of biological aging in mesenchymal stem cells, regulating gene expression related to a variety of functions including cellular proliferation and inflammation.

	All
		Review Strategies for enrichment and selection of stem cell-derived tissue precursors Harold S Bernstein, William C Hyun Stem Cell Research & Therapy 2012, 3:17 (10 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bernstein and Hyun review strategies used to direct tissue-specific differentiation of embryonic stem cells (ESCs), and methods for the identification and selection of tissue-specific precursors for scientific study and clinical use.
		Research The secretome of stem cells isolated from the adipose tissue and Wharton's jelly acts differently on central nervous system-derived cell populations Carlos A Ribeiro, Joana S Fraga, Mario Graos, Nuno M Neves, Rui L Reis, Jeffrey M Gimble, Nuno Sousa, Antonio J Salgado Stem Cell Research & Therapy 2012, 3:18 (2 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The secretome of human umbilical cord perivascular cells (HUPVCs) and adipose tissue-derived stem cells differ, with HUPVC conditioned media able to promote neuronal survival and differentiation without exogenous supplement.
		Editorial Stem Cell Research & Therapy in 2012 Philippa Locke, Rocky S Tuan, Timothy O'Brien Stem Cell Research & Therapy 2012, 3:16 (30 April 2012) Abstract \| Full text \| PDF \| PubMed
		Commentary Colonizing the heart from the epicardial side Nenad Bursac Stem Cell Research & Therapy 2012, 3:15 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nenad Bursac comments on recent research describing a distinct population of epicardium-derived mesenchymal stem cells residing in a perivascular niche of the heart with a broad multilineage potential, and considers future applications.
		Review Orthopaedic applications of nanoparticle-based stem cell therapies Ian Wimpenny, Hareklea Markides, Alicia J El Haj Stem Cell Research & Therapy 2012, 3:13 (19 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alicia El Haj and colleagues review recent research on the applications of iron-oxide-based magnetic nanoparticles to improve how stem cells are controlled, monitored and targeted to sites of repair.
		Research Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome Xiaoning Mou, Yuanbo Wu, Henghua Cao, Qingzhang Meng, Qihui Wang, Chengchao Sun, Shengshou Hu, Yue Ma, Hao Zhang Stem Cell Research & Therapy 2012, 3:14 (18 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The derivation of induced pluripotent stem cells (iPSCs) from two patients with different karyotypes of Down syndrome offers opportunities for disease modeling, drug discovery and potential future cell replacement therapies.
		Review Progress on stem cell research towards the treatment of Parkinson's disease Stuart AJ Gibson, Guo-Dong Gao, Katya McDonagh, Sanbing Shen Stem Cell Research & Therapy 2012, 3:11 (3 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sanbing Shen and colleagues provide an overview of recent progress towards a combined approach of drugs, cell replacement, and gene therapy to halt disease progression and improve treatment of Parkinson's disease.
		Research Production and validation of a good manufacturing practice grade human fibroblast line for supporting human embryonic stem cell derivation and culture Nilendran Prathalingam, Linda Ferguson, Lesley Young, Georg Lietz, Rachel Oldershaw, Lyn Healy, Albert Craig, Helen Lister, Rakesh Binaykia, Radhika Sheth, Alison Murdoch, Mary Herbert Stem Cell Research & Therapy 2012, 3:12 (28 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The human fibroblast line Ncl1Fed1A, produced in compliance with good manufacturing practice (GMP) standards, has been qualified for derivation and maintenance of human embryonic stem cells (hESCs).
		Review Dormancy in the stem cell niche Roberta Sottocornola, Cristina Lo Celso Stem Cell Research & Therapy 2012, 3:10 (19 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sottocornola and Lo Celso review recent findings on dormant hematopoietic stem cells, examining whether the mechanism of dormancy is common amongst regenerating tissues, and discuss implications for cancer therapy.
		Review Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells Tohru Sugawara, Koichiro Nishino, Akihiro Umezawa, Hidenori Akutsu Stem Cell Research & Therapy 2012, 3:8 (8 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hide Akutsu and colleagues review recent research on variation in induced pluripotent stem (iPS) cells, their ability to differentiate and the identity of the differentiated cells.
		Research Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells Adetola B Adesida, Aillette Mulet-Sierra, Nadr M Jomha Stem Cell Research & Therapy 2012, 3:9 (2 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hypoxia-mediated isolation and expansion increases the chondrogenic potential of bone marrow mesenchymal stromal cells (BMSCs) and may improve their clinical applications in cartilage repair.
		Review Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head Lars Rackwitz, Lars Eden, Stephan Reppenhagen, Johannes C Reichert, Franz Jakob, Heike Walles, Oliver Pullig, Rocky S Tuan, Maximilian Rudert, Ulrich Nöth Stem Cell Research & Therapy 2012, 3:7 (22 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ulrich Noth and colleagues review regenerative medicine approaches to treating avascular necrosis of the femoral head, a debilitating disease often leading to osteoarthritis and eventually hip replacement in young adults.
		Research Phenotypical and functional characteristics of mesenchymal stem cells from bone marrow: comparison of culture using different media supplemented with human platelet lysate or fetal bovine serum Nesrine Azouna, Faouzi Jenhani, Zohra Regaya, Lamia Berraeis, Tarek Othman, Elfi Ducrocq, Jorge Domenech Stem Cell Research & Therapy 2012, 3:6 (14 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells expanded in human platelet lysate supplemented media without fetal bovine serum (FBS) retain their phenotype and differentiation capacity, while an increased growth rate may allow for reduced culture time.
		Research Interleukin-1β and transforming growth factor-β cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells Lei Wang, Ziyan Liu, Sivasai Balivada, Tej Shrestha, Stefan Bossmann, Marla Pyle, Loretta Pappan, Jishu Shi, Deryl Troyer Stem Cell Research & Therapy 2012, 3:5 (10 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Glioma cells that fail to self-renew in standard conditions can gain this ability after exposure to IL-1β and TGF-β suggesting targeting glioma stem cell-promoting cytokines may increase the efficacy of glioma therapies.
		Commentary Stem cell-based therapy for α₁-antitrypsin deficiency S Tamir Rashid, David A Lomas Stem Cell Research & Therapy 2012, 3:4 (9 February 2012) Abstract \| Full text \| PDF \| PubMed
		Review The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms Sara Morando, Tiziana Vigo, Marianna Esposito, Simona Casazza, Giovanni Novi, Maria Principato, Roberto Furlan, Antonio Uccelli Stem Cell Research & Therapy 2012, 3:3 (26 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Many studies have demonstrated that mesenchymal stem cells are effective in the treatment of experimental autoimmune encephalomyelitis (EAE) and may have potential as a therapeutic option in multiple sclerosis.
		Review Bone marrow mononuclear cells and acute myocardial infarction Samer Arnous, Abdul Mozid, John Martin, Anthony Mathur Stem Cell Research & Therapy 2012, 3:2 (17 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The use of bone-marrow derived mononuclear cells in cardiac repair after acute myocardial infarction, a leading cause of death and disability, is reviewed by Anthony Mathur and colleagues.
		Commentary When one cell is enough Rhodri Ceredig Stem Cell Research & Therapy 2012, 3:1 (13 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rhodri Ceredig discusses a significant advance in our understanding of human hematopoiesis.
		Review Stem cell therapy for retinal diseases: update Rubens Siqueira Stem Cell Research & Therapy 2011, 2:50 (29 December 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients Reinhold J Medina, Desmond B Archer, Alan W Stitt Stem Cell Research & Therapy 2011, 2:47 (7 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation Tayaramma Thatava, Adam S Armstrong, Josep De Lamo, Ramakrishna Edukulla, Yulia Khan, Toshie Sakuma, Seiga Ohmine, Jamie L Sundsbak, Peter C Harris, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:48 (6 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Disease-specific induced pluripotent stem cells (iPSCs) have been generated from kidney transplant recipients, providing opportunities to study patient-specific disease pathogenesis in vitro and demonstrating potential for autologous kidney replacement therapy.
		Review Finding a niche: studies from the Drosophila ovary Susan Eliazer, Michael Buszczak Stem Cell Research & Therapy 2011, 2:45 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
		Review Uses of cardiomyocytes generated from induced pluripotent stem cells Tung-Ying Lu, Lei Yang Stem Cell Research & Therapy 2011, 2:44 (18 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells Seiga Ohmine, Allan B Dietz, Michael C Deeds, Katherine A Hartjes, David R Miller, Tayaramma Thatava, Toshie Sakuma, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:46 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hematopoietic progenitor cells and peripheral blood mononuclear cells could be ideal somatic cell sources for clinical-grade induced pluripotent stem cell (iPSC) derivation, allowing minimally invasive tissue procurement and rapid cellular reprogramming.
		Research MicroRNA profiling reveals age-dependent differential expression of nuclear factor κB and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells Amitabh C Pandey, Julie A Semon, Deepak Kaushal, Regina P O'Sullivan, Julie Glowacki, Jeffery M Gimble, Bruce A Bunnell Stem Cell Research & Therapy 2011, 2:49 (14 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Differential expression of microRNAs is an integral component of biological aging in mesenchymal stem cells, regulating gene expression related to a variety of functions including cellular proliferation and inflammation.