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Extrinsic regulation of satellite cell specification
C Florian
Bentzinger,
Julia
von Maltzahn,
Michael
A
Rudnicki
Stem Cell Research & Therapy 2010, 1:27 (26 August 2010)
Abstract
| Full text | PDF | PubMed
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Editor’s summary
The existence of numerous physiological factors that are involved in the regulation of satellite cells provides an opportunity for the development of drugs that mimic or interfere with these molecules
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Experimental approaches for the generation of induced pluripotent stem cells
Cesar
A
Sommer,
Gustavo
Mostoslavsky
Stem Cell Research & Therapy 2010, 1:26 (10 August 2010)
Abstract
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Editor’s summary
Sommer and Mostoslavsky summarize current reprogramming methodologies, focusing on the production of genetically unmanipulated induced pluripotent stem (iPS) cells, highlighting important technical details that could influence the biological properties of these cells.
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Advances in mesenchymal stem cell-mediated gene therapy for cancer
Roisin
M
Dwyer,
Sonja
Khan,
Frank
P
Barry,
Timothy
O'Brien,
Michael
J
Kerin
Stem Cell Research & Therapy 2010, 1:25 (9 August 2010)
Abstract
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Editor’s summary
Exploiting the tumour-homing capacity of mesenchymal stem cells (MSCs) for gene delivery has potential for MSC-mediated delivery of therapeutic agents directly to tumour tissue.
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Systems biology discoveries using non-human primate pluripotent stem and germ cells: novel gene and genomic imprinting interactions as well as unique expression patterns
Ahmi
Ben-Yehudah,
Charles
A
Easley,
Brian
P
Hermann,
Carlos
Castro,
Calvin
Simerly,
Kyle
E
Orwig,
Shoukhrat
Mitalipov,
Gerald
Schatten
Stem Cell Research & Therapy 2010, 1:24 (5 August 2010)
Abstract
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Editor’s summary
Ben-Yehudah et al. review mRNAs and novel genes with unique expression and imprinting patterns discovered using systems biology approaches with primate pluripotent stem and germ cells.
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Efficient, high-throughput transfection of human embryonic stem cells
Jennifer
C
Moore,
Kristin
Atze,
Percy
L
Yeung,
Alana
J
Toro-Ramos,
Cynthia
Camarillo,
Kevin
Thompson,
Christopher
L
Ricupero,
Mark
A
Brenneman,
Rick
I
Cohen,
Ronald
P
Hart
Stem Cell Research & Therapy 2010, 1:23 (26 July 2010)
Abstract
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Controlling the direction of division
Peter
Satir
Stem Cell Research & Therapy 2010, 1:21 (23 July 2010)
Abstract
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Human CD34+ cells mobilized by granulocyte colony-stimulating factor ameliorate radiation-induced liver damage in mice
Ning
Li,
Li
Zhang,
Huixiang
Li,
Baijun
Fang
Stem Cell Research & Therapy 2010, 1:22 (15 July 2010)
Abstract
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Editor’s summary
Treatment with granulocyte colony-stimulating factor-mobilized CD34+ hematopoietic stem cells from bone marrow into peripheral blood could promote tissue reparation after acute liver injury by radiation in mice.
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Murine amniotic fluid stem cells contribute mesenchymal but not epithelial components to reconstituted mammary ducts
Petra
AB
Klemmt,
Vida
Vafaizadeh,
Bernd
Groner
Stem Cell Research & Therapy 2010, 1:20 (7 July 2010)
Abstract
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Editor’s summary
Microenvironmental cues of the mammary fat pad cause amniotic fluid stem cells to form a supportive stroma for extending ductal epithelium, but don’t incorporate or differentiate into ductal epithelial cells.
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Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
Jeffrey
M
Gimble,
Farshid
Guilak,
Bruce
A
Bunnell
Stem Cell Research & Therapy 2010, 1:19 (29 June 2010)
Abstract
| Full text | PDF | PubMed
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Editor’s summary
Gimble et al. review the clinical evidence using autologous adipose-derived cells that have been published in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines.
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Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype
Casey
L
Korecki,
Juan
M
Taboas,
Rocky
S
Tuan,
James
C
Iatridis
Stem Cell Research & Therapy 2010, 1:18 (16 June 2010)
Abstract
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Editor’s summary
Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation towards nucleus pulposus-like phenotype with characteristics of the developing intervertebral disc (IVD), suggesting notochordal cells as a promising target for IVD repair.
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Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: a longitudinal imaging study
Johanna
S
Jackson,
Jon
P
Golding,
Catherine
Chapon,
William
A
Jones,
Kishore
K
Bhakoo
Stem Cell Research & Therapy 2010, 1:17 (15 June 2010)
Abstract
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Mesenchymal stem cells immunosuppressive properties: is it specific to bone marrow-derived cells?
Christian
Jorgensen
Stem Cell Research & Therapy 2010, 1:15 (8 June 2010)
Abstract
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Editor’s summary
Findings that immunosuppressive properties are probably shared by all stromal cells including fibroblasts and stem cells isolated from exfoliated deciduous teeth may have clinical implications.
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Comment on basal epithelial stem cells as efficient targets for prostate cancer initiation
Letitia
Wong,
Wade
Bushman
Stem Cell Research & Therapy 2010, 1:16 (8 June 2010)
Abstract
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Editor’s summary
Wong and Bushman comment on a recent study showing cells with stem cell properties can undergo oncogenic transformation and produce prostate mouse lesions resembling different grades of human prostate cancer.
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Cancerous stem cells: deviant stem cells with cancer-causing misbehavior
Julie
M
Chandler,
Eric
Lagasse
Stem Cell Research & Therapy 2010, 1:13 (20 May 2010)
Abstract
| Full text | PDF | PubMed
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Editor’s summary
Cancerous stem cells, the result of changes in signaling pathways involved in stem cell survival and proliferation, show resistance to cancer therapies, and understanding their unique characteristics is key to targeting therapies towards them.
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Tbx3: another important piece fitted into the pluripotent stem cell puzzle
Melinda
K
Pirity,
Andras
Dinnyes
Stem Cell Research & Therapy 2010, 1:12 (20 May 2010)
Abstract
| Full text | PDF | PubMed
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Editor’s summary
Pirity and Dinnyes discuss the recent finding that T box gene 3 can improve the quality of induced pluripotent stem cells (iPSCs) and the potential implication this may have on improving iPSC technology.
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Expression of migration-related genes is progressively upregulated in murine Lineage-Sca-1+c-Kit+ population from the fetal to adult stages of development
Jesús
Ciriza,
Marcos
E
García-Ojeda
Stem Cell Research & Therapy 2010, 1:14 (20 May 2010)
Abstract
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Editor’s summary
Migration-related genes are progressively upregulated in a murine Lineage-Sca-1+c-Kit+ cell population during their transition to the bone marrow microenvironment.
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Activin A expression regulates multipotency of mesenchymal progenitor cells
Farida
Djouad,
Wesley
M
Jackson,
Brent
E
Bobick,
Sasa
Janjanin,
Yingjie
Song,
George
TJ
Huang,
Rocky
S
Tuan
Stem Cell Research & Therapy 2010, 1:11 (4 May 2010)
Abstract
| Full text | PDF | PubMed
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Editor’s summary
Activin A expression acts as a functional marker for multipotent mesenchymal progenitor cells, allowing for identification of the more desirable cell types for use in regenerative medicine.
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Bone tissue engineering with human stem cells
Darja
Marolt,
Miomir
Knezevic,
Gordana
Novakovic
Stem Cell Research & Therapy 2010, 1:10 (4 May 2010)
Abstract
| Full text | PDF | PubMed
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Editor’s summary
Using human stem cells for bone tissue engineering may be a viable alternative to treating bone defects with autologous bone grafting or implanting bone substitute materials.
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Challenges in the clinical application of induced pluripotent stem cells
Douglas
Sipp
Stem Cell Research & Therapy 2010, 1:9 (12 April 2010)
Abstract
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Editor’s summary
Douglas Sipp outlines the challenges faced in the clinical application of human induced pluripotent (iPS) stem cells, and argues that confronting the problems will facilitate revolutionary advances in cell therapy.
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A novel serum-free medium for the expansion of human mesenchymal stem cells
Lucas
G
Chase,
Uma
Lakshmipathy,
Luis
A
Solchaga,
Mahendra
S
Rao,
Mohan
C
Vemuri
Stem Cell Research & Therapy 2010, 1:8 (2 April 2010)
Abstract
| Full text | PDF | PubMed
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Editor’s summary
A novel serum-free mesenchymal stem cell culture medium could substitute ill-defined traditional culture medium for research applications – an important step in the development of a more clinically relevant culture system.
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Selection and reliability of internal reference genes for quantitative PCR verification of transcriptomics during the differentiation process of porcine adult mesenchymal stem cells
Elisa
Monaco,
Massimo
Bionaz,
Alecsandra
de Lima,
Walter
L
Hurley,
Juan
J
Loor,
Matthew
B
Wheeler
Stem Cell Research & Therapy 2010, 1:7 (30 March 2010)
Abstract
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Editor’s summary
A new protocol, combining microarray data with pair-wise gene analysis, identified novel reliable housekeeping genes for data normalization of adult porcine stem cells, and can be used in other similar experiments.
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Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications
Soufiane
Ghannam,
Carine
Bouffi,
Farida
Djouad,
Christian
Jorgensen,
Danièle
Noël
Stem Cell Research & Therapy 2010, 1:2 (15 March 2010)
Abstract
| Full text | PDF | PubMed
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Editor’s summary
Ghannam et al discuss the targets and mechanisms of mesenchymal stem cell (MSC)-mediated immunosuppression, and the potential use of MSCs to modulate immune responses in a variety of autoimmune diseases.
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Epigenetics of induced pluripotency, the seven-headed dragon
Ugljesa
Djuric,
James
Ellis
Stem Cell Research & Therapy 2010, 1:3 (15 March 2010)
Abstract
| Full text | PDF | PubMed
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Editor’s summary
Djuric and Ellis highlight advancements in the understanding of dynamic epigenetic changes occurring in the cell reprogramming process, and how aberrant epigenetic remodeling may impact on applications of iPS cell technology.
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Welcome to Stem Cell Research & Therapy
Ann
Donnelly,
Surayya
Johar,
Timothy
O'Brien,
Rocky
S
Tuan
Stem Cell Research & Therapy 2010, 1:1 (15 March 2010)
Abstract
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Editor’s summary
Timothy O’Brien and Rocky Tuan, Editors-in-Chief, introduce Stem Cell Research & Therapy, the major forum for translational research into stem cell therapies.
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Cell distribution after intracoronary bone marrow stem cell delivery in damaged and undamaged myocardium: implications for clinical trials
Virginie
F
Forest,
Ashok
M
Tirouvanziam,
Christian
Perigaud,
Sarah
Fernandes,
Marion
S
Fusellier,
Jean-Claude
Desfontis,
Claire
S
Toquet,
Marie-Françoise
M
Heymann,
Dominique
P
Crochet,
Patricia
F
Lemarchand
Stem Cell Research & Therapy 2010, 1:4 (15 March 2010)
Abstract
| Full text | PDF | PubMed
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Editor’s summary
Myocardial cell distribution after intracoronary injection did not depend on myocardial infarction (MI) presence, in a porcine model, which could be useful for cardiac cell therapy in patients with heart failure without MI.
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