Stem Cell Research & Therapy

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		Review The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms Sara Morando, Tiziana Vigo, Marianna Esposito, Simona Casazza, Giovanni Novi, Maria Principato, Roberto Furlan, Antonio Uccelli Stem Cell Research & Therapy 2012, 3:3 (26 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Many studies have demonstrated that mesenchymal stem cells are effective in the treatment of experimental autoimmune encephalomyelitis (EAE) and may have potential as a therapeutic option in multiple sclerosis.
		Review Bone marrow mononuclear cells and acute myocardial infarction Samer Arnous, Abdul Mozid, John Martin, Anthony Mathur Stem Cell Research & Therapy 2012, 3:2 (17 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The use of bone-marrow derived mononuclear cells in cardiac repair after acute myocardial infarction, a leading cause of death and disability, is reviewed by Anthony Mathur and colleagues.
		Commentary When one cell is enough Rhodri Ceredig Stem Cell Research & Therapy 2012, 3:1 (13 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rhodri Ceredig discusses a significant advance in our understanding of human hematopoiesis.
		Review Stem cell therapy for retinal diseases: update Rubens Siqueira Stem Cell Research & Therapy 2011, 2:50 (29 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research MicroRNA profiling reveals age dependent differential expression of nuclear factor kappa B and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells cells Amitabh C Pandey, Julie Semon, Deepak Kaushal, Regina P O'Sullivan, Julie Glowacki, Jeffery M Gimble, Bruce A Bunnell Stem Cell Research & Therapy 2011, 2:49 (14 December 2011) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Differential expression of microRNAs is an integral component of biological aging in mesenchymal stem cells, regulating gene expression related to a variety of functions including cellular proliferation and inflammation.
		Commentary Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients Reinhold J Medina, Desmond B Archer, Alan W Stitt Stem Cell Research & Therapy 2011, 2:47 (7 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation Tayaramma Thatava, Adam S Armstrong, Josep De Lamo, Ramakrishna Edukulla, Yulia Khan, Toshie Sakuma, Seiga Ohmine, Jamie L Sundsbak, Peter C Harris, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:48 (6 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Disease-specific induced pluripotent stem cells (iPSCs) have been generated from kidney transplant recipients, providing opportunities to study patient-specific disease pathogenesis in vitro and demonstrating potential for autologous kidney replacement therapy.
		Review Finding a niche: studies from the Drosophila ovary Susan Eliazer, Michael Buszczak Stem Cell Research & Therapy 2011, 2:45 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
		Review Uses of cardiomyocytes generated from induced pluripotent stem cells Tung-Ying Lu, Lei Yang Stem Cell Research & Therapy 2011, 2:44 (18 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells Seiga Ohmine, Allan B Dietz, Michael C Deeds, Katherine A Hartjes, David R Miller, Tayaramma Thatava, Toshie Sakuma, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:46 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hematopoietic progenitor cells and peripheral blood mononuclear cells could be ideal somatic cell sources for clinical-grade induced pluripotent stem cell (iPSC) derivation, allowing minimally invasive tissue procurement and rapid cellular reprogramming.
		Commentary Cell therapy for refractory angina: time for more ACTion Peter J Psaltis, Robert D Simari Stem Cell Research & Therapy 2011, 2:43 (9 November 2011) Abstract \| Full text \| PDF \| PubMed
		Review DNA methylation in stem cell renewal and multipotency María Berdasco, Manel Esteller Stem Cell Research & Therapy 2011, 2:42 (31 October 2011) Abstract \| Full text \| PDF \| PubMed
		Viewpoint Lung stem cells - from an evolving understanding to a paradigm shift? Mairéad Hayes, Gerard F Curley, John G Laffey Stem Cell Research & Therapy 2011, 2:41 (20 October 2011) Abstract \| Full text \| PDF \| PubMed
		Review Stem cell applications in military medicine Gregory T Christopherson, Leon J Nesti Stem Cell Research & Therapy 2011, 2:40 (19 October 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Amyloid precursor protein: more than just neurodegeneration Sanjay W Pimplikar, Kaushik Ghosal Stem Cell Research & Therapy 2011, 2:39 (14 October 2011) Abstract \| Full text \| PDF \| PubMed
		Research Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia Jung Lim, Chang Jeong, Jin Jun, Seong Kim, Chung Ryu, Yun Hou, Wonil Oh, Jong Chang, Sin-Soo Jeun Stem Cell Research & Therapy 2011, 2:38 (22 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells administered intrathecally by lumbar puncture significantly reduced ischemic damage in a stroke-affected rat model, demonstrating the potential of this delivery method in the treatment of brain injuries or neurodegenerative disorders.
		Review Induced pluripotent stem cells in the study of neurological diseases Mario A Saporta, Marica Grskovic, John T Dimos Stem Cell Research & Therapy 2011, 2:37 (21 September 2011) Abstract \| Full text \| PDF \| PubMed
		Research Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin Michael P Demars, Amelia Bartholomew, Zuzana Strakova, Orly Lazarov Stem Cell Research & Therapy 2011, 2:36 (30 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Soluble amyloid precursor protein alpha (sAPPα) regulates the proliferation of adult neural progenitor cells, mesenchymal stem cells and human placenta-derived stem cells by signalling through mitogen-activated protein kinase pathways.
		Commentary Doing the dirty work: progress in the search for a reliable protocol for cardiomyogenesis Jennifer K Redig, Eric Adler Stem Cell Research & Therapy 2011, 2:35 (15 August 2011) Abstract \| Full text \| PDF \| PubMed
		Review Mesenchymal stem cell effects on T-cell effector pathways Michelle M Duffy, Thomas Ritter, Rhodri Ceredig, Matthew D Griffin Stem Cell Research & Therapy 2011, 2:34 (11 August 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Promise of periodontal ligament stem cells in regeneration of periodontium Hidefumi Maeda, Atsushi Tomokiyo, Shinsuke Fujii, Naohisa Wada, Akifumi Akamine Stem Cell Research & Therapy 2011, 2:33 (28 July 2011) Abstract \| Full text \| PDF \| PubMed
		Review The role of induced pluripotent stem cells in regenerative medicine: neurodegenerative diseases Jun Peng, Xianmin Zeng Stem Cell Research & Therapy 2011, 2:32 (28 July 2011) Abstract \| Full text \| PDF \| PubMed
		Review Terminal differentiation is not a major determinant for the success of stem cell therapy - cross-talk between muscle-derived stem cells and host cells Burhan Gharaibeh, Mitra Lavasani, James H Cummins, Johnny Huard Stem Cell Research & Therapy 2011, 2:31 (8 July 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Epidermal stem cell dynamics Maya Sieber-Blum Stem Cell Research & Therapy 2011, 2:29 (29 June 2011) Abstract \| Full text \| PDF \| PubMed
		Review The role of p21 in regulating mammalian regeneration Larry Arthur, Ellen Heber-Katz Stem Cell Research & Therapy 2011, 2:30 (29 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Larry Arthur and Ellen Heber-Katz review their recent results demonstrating p21 knockout can activate regenerative capacity in a mouse model and speculate on the role of p21 in regeneration.

	All
		Review The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms Sara Morando, Tiziana Vigo, Marianna Esposito, Simona Casazza, Giovanni Novi, Maria Principato, Roberto Furlan, Antonio Uccelli Stem Cell Research & Therapy 2012, 3:3 (26 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Many studies have demonstrated that mesenchymal stem cells are effective in the treatment of experimental autoimmune encephalomyelitis (EAE) and may have potential as a therapeutic option in multiple sclerosis.
		Review Bone marrow mononuclear cells and acute myocardial infarction Samer Arnous, Abdul Mozid, John Martin, Anthony Mathur Stem Cell Research & Therapy 2012, 3:2 (17 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The use of bone-marrow derived mononuclear cells in cardiac repair after acute myocardial infarction, a leading cause of death and disability, is reviewed by Anthony Mathur and colleagues.
		Commentary When one cell is enough Rhodri Ceredig Stem Cell Research & Therapy 2012, 3:1 (13 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rhodri Ceredig discusses a significant advance in our understanding of human hematopoiesis.
		Review Stem cell therapy for retinal diseases: update Rubens Siqueira Stem Cell Research & Therapy 2011, 2:50 (29 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research MicroRNA profiling reveals age dependent differential expression of nuclear factor kappa B and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells cells Amitabh C Pandey, Julie Semon, Deepak Kaushal, Regina P O'Sullivan, Julie Glowacki, Jeffery M Gimble, Bruce A Bunnell Stem Cell Research & Therapy 2011, 2:49 (14 December 2011) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Differential expression of microRNAs is an integral component of biological aging in mesenchymal stem cells, regulating gene expression related to a variety of functions including cellular proliferation and inflammation.
		Commentary Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients Reinhold J Medina, Desmond B Archer, Alan W Stitt Stem Cell Research & Therapy 2011, 2:47 (7 December 2011) Abstract \| Full text \| PDF \| PubMed
		Research Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation Tayaramma Thatava, Adam S Armstrong, Josep De Lamo, Ramakrishna Edukulla, Yulia Khan, Toshie Sakuma, Seiga Ohmine, Jamie L Sundsbak, Peter C Harris, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:48 (6 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Disease-specific induced pluripotent stem cells (iPSCs) have been generated from kidney transplant recipients, providing opportunities to study patient-specific disease pathogenesis in vitro and demonstrating potential for autologous kidney replacement therapy.
		Review Finding a niche: studies from the Drosophila ovary Susan Eliazer, Michael Buszczak Stem Cell Research & Therapy 2011, 2:45 (25 November 2011) Abstract \| Full text \| PDF \| PubMed
		Review Uses of cardiomyocytes generated from induced pluripotent stem cells Tung-Ying Lu, Lei Yang Stem Cell Research & Therapy 2011, 2:44 (18 November 2011) Abstract \| Full text \| PDF \| PubMed
		Research Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells Seiga Ohmine, Allan B Dietz, Michael C Deeds, Katherine A Hartjes, David R Miller, Tayaramma Thatava, Toshie Sakuma, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:46 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hematopoietic progenitor cells and peripheral blood mononuclear cells could be ideal somatic cell sources for clinical-grade induced pluripotent stem cell (iPSC) derivation, allowing minimally invasive tissue procurement and rapid cellular reprogramming.
		Commentary Cell therapy for refractory angina: time for more ACTion Peter J Psaltis, Robert D Simari Stem Cell Research & Therapy 2011, 2:43 (9 November 2011) Abstract \| Full text \| PDF \| PubMed
		Review DNA methylation in stem cell renewal and multipotency María Berdasco, Manel Esteller Stem Cell Research & Therapy 2011, 2:42 (31 October 2011) Abstract \| Full text \| PDF \| PubMed
		Viewpoint Lung stem cells - from an evolving understanding to a paradigm shift? Mairéad Hayes, Gerard F Curley, John G Laffey Stem Cell Research & Therapy 2011, 2:41 (20 October 2011) Abstract \| Full text \| PDF \| PubMed
		Review Stem cell applications in military medicine Gregory T Christopherson, Leon J Nesti Stem Cell Research & Therapy 2011, 2:40 (19 October 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Amyloid precursor protein: more than just neurodegeneration Sanjay W Pimplikar, Kaushik Ghosal Stem Cell Research & Therapy 2011, 2:39 (14 October 2011) Abstract \| Full text \| PDF \| PubMed
		Research Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia Jung Lim, Chang Jeong, Jin Jun, Seong Kim, Chung Ryu, Yun Hou, Wonil Oh, Jong Chang, Sin-Soo Jeun Stem Cell Research & Therapy 2011, 2:38 (22 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells administered intrathecally by lumbar puncture significantly reduced ischemic damage in a stroke-affected rat model, demonstrating the potential of this delivery method in the treatment of brain injuries or neurodegenerative disorders.
		Review Induced pluripotent stem cells in the study of neurological diseases Mario A Saporta, Marica Grskovic, John T Dimos Stem Cell Research & Therapy 2011, 2:37 (21 September 2011) Abstract \| Full text \| PDF \| PubMed
		Research Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin Michael P Demars, Amelia Bartholomew, Zuzana Strakova, Orly Lazarov Stem Cell Research & Therapy 2011, 2:36 (30 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Soluble amyloid precursor protein alpha (sAPPα) regulates the proliferation of adult neural progenitor cells, mesenchymal stem cells and human placenta-derived stem cells by signalling through mitogen-activated protein kinase pathways.
		Commentary Doing the dirty work: progress in the search for a reliable protocol for cardiomyogenesis Jennifer K Redig, Eric Adler Stem Cell Research & Therapy 2011, 2:35 (15 August 2011) Abstract \| Full text \| PDF \| PubMed
		Review Mesenchymal stem cell effects on T-cell effector pathways Michelle M Duffy, Thomas Ritter, Rhodri Ceredig, Matthew D Griffin Stem Cell Research & Therapy 2011, 2:34 (11 August 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Promise of periodontal ligament stem cells in regeneration of periodontium Hidefumi Maeda, Atsushi Tomokiyo, Shinsuke Fujii, Naohisa Wada, Akifumi Akamine Stem Cell Research & Therapy 2011, 2:33 (28 July 2011) Abstract \| Full text \| PDF \| PubMed
		Review The role of induced pluripotent stem cells in regenerative medicine: neurodegenerative diseases Jun Peng, Xianmin Zeng Stem Cell Research & Therapy 2011, 2:32 (28 July 2011) Abstract \| Full text \| PDF \| PubMed
		Review Terminal differentiation is not a major determinant for the success of stem cell therapy - cross-talk between muscle-derived stem cells and host cells Burhan Gharaibeh, Mitra Lavasani, James H Cummins, Johnny Huard Stem Cell Research & Therapy 2011, 2:31 (8 July 2011) Abstract \| Full text \| PDF \| PubMed
		Commentary Epidermal stem cell dynamics Maya Sieber-Blum Stem Cell Research & Therapy 2011, 2:29 (29 June 2011) Abstract \| Full text \| PDF \| PubMed
		Review The role of p21 in regulating mammalian regeneration Larry Arthur, Ellen Heber-Katz Stem Cell Research & Therapy 2011, 2:30 (29 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Larry Arthur and Ellen Heber-Katz review their recent results demonstrating p21 knockout can activate regenerative capacity in a mouse model and speculate on the role of p21 in regeneration.