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Improving outcomes of acute kidney injury using mouse renal progenitor cells alone or in combination with erythropoietin or suramin
Xiao Han, Li Zhao, Guodong Lu, Junke Ge, Yalin Zhao, Shulu Zu, Mingzhen Yuan, Yuqiang Liu, Feng Kong, Zhiying Xiao, Shengtian Zhao Stem Cell Research & Therapy 2013, 4:74 (18 June 2013)
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Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells
Wai Lim, Tomoko Inoue-Yokoo, Keai Tan, Mei I Lai, Daisuke Sugiyama Stem Cell Research & Therapy 2013, 4:71 (18 June 2013)
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Human induced pluripotent stem cell-derived neural stem cells survive, migrate, differentiate, and improve neurological function in a rat model of middle cerebral artery occlusion
Ting Yuan, Wei Liao, Nian-Hua Feng, Yuan-Lei Lou, Xin Niu, Ai-Jun Zhang, Yang Wang, Zhi-Feng Deng Stem Cell Research & Therapy 2013, 4:73 (14 June 2013)
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Topical administration of orbital fat-derived stem cells promotes corneal tissue regeneration
Ko-Jo Lin, Mei-Xue Loi, Gi-Shih Lien, Chieh-Feng Cheng, Hsiang-Yin Pao, Yun-Chuang Chang, Andrea Tung-Qian Ji, Jennifer Hui-Chun Ho Stem Cell Research & Therapy 2013, 4:72 (14 June 2013)
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Editor’s summary
Topical administration of orbital fat-derived stem cells (OFSCs) promotes corneal tissue regeneration in a mouse model of corneal injury through corneal epithelial differentiation of OFSCs and by inhibiting inflammation.
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Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors
Ting Zhang, Yuk Wai Lee, Yun Feng Rui, Tin Yan Cheng, Xiao Hua Jiang, Gang Li Stem Cell Research & Therapy 2013, 4:70 (13 June 2013)
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Editor’s summary
Bone marrow-derived mesenchymal stem cells promote tumor cell proliferation in vitro and tumor growth in vivo, which may be attributed to increased expression of pro-angiogenic factors in the tumor microenvironment.
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Human neural stem cell transplantation in spinal cord injury models: how far from clinical application?
Isaura Tavares Stem Cell Research & Therapy 2013, 4:61 (13 June 2013)
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Conditionally immortalized stem cell lines from human spinal cord retain regional identity and generate functional V2a interneurons and motorneurons
Graham Cocks, Nataliya Romanyuk, Takashi Amemori, Pavla Jendelova, Oksana Forostyak, Aaron R Jeffries, Leo Perfect, Sandrine Thuret, Govindan Dayanithi, Eva Sykova, Jack Price Stem Cell Research & Therapy 2013, 4:69 (7 June 2013)
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Editor’s summary
Immortalized neural stem cell lines derived from human fetal spinal cord retain their identity after extensive in vitro propagation and differentiate into relevant ventral interneurons and motorneurons.
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Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat
Takashi Amemori, Nataliya Romanyuk, Pavla Jendelova, Vit Herynek, Karolina Turnovcova, Pavel Prochazka, Miroslava Kapcalova, Graham Cocks, Jack Price, Eva Sykova Stem Cell Research & Therapy 2013, 4:68 (7 June 2013)
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Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors
Paola Romina Amable, Rosana Bizon Carias, Marcus Vinicius Teixeira, Ítalo da Pacheco, Ronaldo José do Amaral, José Mauro Granjeiro, Radovan Borojevic Stem Cell Research & Therapy 2013, 4:67 (7 June 2013)
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Editor’s summary
Optimization and standardization of platelet-rich plasma preparation yields a cytokine and growth factor pool from different donors with high reproducibility for therapeutic use.
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Production of mesenchymal stromal/stem cells according to good manufacturing practices: a review
Luc Sensebé, Mélanie Gadelorge, Sandrine Fleury-Cappellesso Stem Cell Research & Therapy 2013, 4:66 (7 June 2013)
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Immunoregulatory properties of clinical grade mesenchymal stromal cells: evidence, uncertainties, and clinical application
Cédric Ménard, Karin Tarte Stem Cell Research & Therapy 2013, 4:64 (6 June 2013)
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Pre-conditioned mesenchymal stem cells: a better way for cell-based therapy
Qing Li, Yang Wang, Zhifeng Deng Stem Cell Research & Therapy 2013, 4:63 (5 June 2013)
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Editor’s summary
Zhifeng Deng and colleagues comment on recent research suggesting mesenchymal stem cells pre-conditioned with oxidative reagents show improved cardiac differentiation efficiency and the implications for cell therapy in ischemic heart disease.
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Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells
Patricia Luz-Crawford, Monica Kurte, Javiera Bravo-Alegría, Rafael Contreras, Estefania Nova Lamperti, Gautier Tejedor, Danièle Noël, Christian Jorgensen, Fernando Figueroa, Farida Djouad, Flavio Carrión Stem Cell Research & Therapy 2013, 4:65 (4 June 2013)
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Editor’s summary
Mesenchymal stem cells inhibit the differentiation of Th1 and Th17 cells into proinflammatory T cells, and promote the generation of regulatory T cells, with potential applications in inflammatory and autoimmune diseases.
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Human Wharton’s jelly-derived mesenchymal stromal cells reduce renal fibrosis through induction of native and foreign hepatocyte growth factor synthesis in injured tubular epithelial cells
Tao Du, Xiangyu Zou, Jun Cheng, Shuai Wu, Liang Zhong, Guanqun Ju, Jiang Zhu, Guohua Liu, Yingjian Zhu, Shujie Xia Stem Cell Research & Therapy 2013, 4:59 (4 June 2013)
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Therapeutic effects of mesenchymal stem cells on renal ischemia–reperfusion injury: a matter of genetic transfer?
Stefania Bruno, Benedetta Bussolati Stem Cell Research & Therapy 2013, 4:55 (4 June 2013)
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Cyclosporine-assisted adipose-derived mesenchymal stem cell therapy to mitigate acute kidney ischemia–reperfusion injury
Yen-Ta Chen, Chih-Chau Yang, Yen-Yi Zhen, Christopher Wallace, Jenq-Lin Yang, Cheuk-Kwan Sun, Tzu-Hsien Tsai, Jiunn-Jye Sheu, Sarah Chua, Chia-Lo Chang, Chung-Lung Cho, Steve Leu, Hon-Kan Yip Stem Cell Research & Therapy 2013, 4:62 (31 May 2013)
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Editor’s summary
Combining cyclosporine and adipose-derived stem cell therapy offers improved protection against ischemia-reperfusion-induced acute kidney injury in rats than either therapy alone, with potential clinical relevance in renal transplantation
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Opportunities and barriers to establishing a cell therapy programme in South Africa
Carlo Jackson, Michael S Pepper Stem Cell Research & Therapy 2013, 4:54 (29 May 2013)
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Editor’s summary
Jackson and Pepper review the factors in favour of establishing a cell therapy programme in South Africa and the problems which would need to be overcome, such as lack of human resources and funding.
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Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation
Sebastiaan van Gorp, Marjolein Leerink, Osamu Kakinohana, Oleksandr Platoshyn, Camila Santucci, Jan Galik, Elbert A Joosten, Marian Hruska-Plochan, Danielle Goldberg, Silvia Marsala, Karl Johe, Joseph D Ciacci, Martin Marsala Stem Cell Research & Therapy 2013, 4:57 (28 May 2013)
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Editor’s summary
Human foetal stem cell grafts improve both motor and sensory functions in rats suffering from a spinal cord injury, demonstrating potential for cell replacement therapy in human spinal cord injuries.
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3′,4′-Dimethoxyflavone and valproic acid promotes the proliferation of human hematopoietic stem cells
Kiranpreet Kaur, Mohammad Mirlashari, Gunnar Kvalheim, Jens Kjeldsen-Kragh Stem Cell Research & Therapy 2013, 4:60 (24 May 2013)
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Editor’s summary
Culturing hematopoietic stem cells with 3',4'-dimethoxyflavone promotes their proliferation and may be useful, along with valporic acid, in the production of such cells for transplantation, cell and gene therapy.
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Preconditioning diabetic mesenchymal stem cells with myogenic medium increases their ability to repair diabetic heart
Mohsin Khan, Fatima Ali, Sadia Mohsin, Shoaib Akhtar, Azra Mehmood, Mahmood S Choudhery, Shaheen N Khan, Sheikh Riazuddin Stem Cell Research & Therapy 2013, 4:58 (24 May 2013)
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Preconditioning diabetic mouse mesenchymal stem cells with myogenic medium improves their survival, proliferation and angiogenic ability in vitro and enhances cardiac repair in vivo after transplantation into diabetic mice.
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CD70–CD27 ligation between neural stem cells and CD4+ T cells induces Fas–FasL-mediated T-cell death
Eun Mi Lee, Sunghoon Hurh, Bumrae Cho, Kook-Hwan Oh, Seung U Kim, Charles D Surh, Jonathan Sprent, Jaeseok Yang, Jae Young Kim, Curie Ahn Stem Cell Research & Therapy 2013, 4:56 (21 May 2013)
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Editor’s summary
Maintaining CD70 expression may enable continued immune escape in neural stem cell (NSC) transplantation as interaction between CD70 on NSCs and CD27 on T cells initiates NSC-induced CD4+ T cell apoptosis.
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Human amniotic fluid-derived and dental pulp-derived stem cells seeded into collagen scaffold repair critical-size bone defects promoting vascularization
Tullia Maraldi, Massimo Riccio, Alessandra Pisciotta, Manuela Zavatti, Gianluca Carnevale, Francesca Beretti, Giovanni B La Sala, Antonella Motta, Anto De Pol Stem Cell Research & Therapy 2013, 4:53 (21 May 2013)
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Editor’s summary
Dental pulp- and amniotic fluid-derived stem cells seeded into collagen scaffolds repair large cranial bone defects in a rat model and are involved in vascularization of the implant.
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Endothelial microvascular networks affect gene-expression profiles and osteogenic potential of tissue-engineered constructs
Torbjorn O Pedersen, Anna L Blois, Zhe Xing, Ying Xue, Yang Sun, Anna Finne-Wistrand, Lars A Akslen, James B Lorens, Knut N Leknes, Inge Fristad, Kamal Mustafa Stem Cell Research & Therapy 2013, 4:52 (17 May 2013)
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Editor’s summary
Copolymer scaffolds can be prevascularized with endothelial cells (EC) and mesenchymal stem cells (MSC); seeding of MSC with or without EC increases the osteogenic potential of tissue-engineered constructs.
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Monitoring neurodegeneration in diabetes using adult neural stem cells derived from the olfactory bulb
Ryo Hidaka, Masanao Machida, Shin Fujimaki, Kazuyuki Terashima, Makoto Asashima, Tomoko Kuwabara Stem Cell Research & Therapy 2013, 4:51 (14 May 2013)
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Editor’s summary
Adult neural stem cells extracted from the olfactory bulb of diabetic rats can be cultured in vitro and show similar gene expression profiles to hippocampal neural stem cells during diabetes progression.
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Age-associated changes in the ecological niche: implications for mesenchymal stem cell aging
Faizal Z Asumda Stem Cell Research & Therapy 2013, 4:47 (14 May 2013)
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