Stem Cell Research & Therapy | Volume 1 Issue 1

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	Volume 1 Issue 1
	Comment
	Editorial Welcome to Stem Cell Research & Therapy Ann Donnelly, Surayya Johar, Timothy O'Brien, Rocky S Tuan Stem Cell Research & Therapy 2010, 1:1 (15 March 2010) Full text \| PDF \| PubMed \| Editor’s summary Timothy O’Brien and Rocky Tuan, Editors-in-Chief, introduce Stem Cell Research & Therapy, the major forum for translational research into stem cell therapies.
	Commentary Challenges in the clinical application of induced pluripotent stem cells Douglas Sipp Stem Cell Research & Therapy 2010, 1:9 (12 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Douglas Sipp outlines the challenges faced in the clinical application of human induced pluripotent (iPS) stem cells, and argues that confronting the problems will facilitate revolutionary advances in cell therapy.
	Review
	Review Epigenetics of induced pluripotency, the seven-headed dragon Ugljesa Djuric, James Ellis Stem Cell Research & Therapy 2010, 1:3 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Djuric and Ellis highlight advancements in the understanding of dynamic epigenetic changes occurring in the cell reprogramming process, and how aberrant epigenetic remodeling may impact on applications of iPS cell technology.
	Review Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications Soufiane Ghannam, Carine Bouffi, Farida Djouad, Christian Jorgensen, Danièle Noël Stem Cell Research & Therapy 2010, 1:2 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ghannam et al discuss the targets and mechanisms of mesenchymal stem cell (MSC)-mediated immunosuppression, and the potential use of MSCs to modulate immune responses in a variety of autoimmune diseases.
	Research
	Research Cell distribution after intracoronary bone marrow stem cell delivery in damaged and undamaged myocardium: implications for clinical trials Virginie F Forest, Ashok M Tirouvanziam, Christian Perigaud, Sarah Fernandes, Marion S Fusellier, Jean-Claude Desfontis, Claire S Toquet, Marie-Françoise M Heymann, Dominique P Crochet, Patricia F Lemarchand Stem Cell Research & Therapy 2010, 1:4 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Myocardial cell distribution after intracoronary injection did not depend on myocardial infarction (MI) presence, in a porcine model, which could be useful for cardiac cell therapy in patients with heart failure without MI.
	Research Immunomodulatory properties of stem cells from human exfoliated deciduous teeth Takayoshi Yamaza, Akiyama Kentaro, Chider Chen, Yi Liu, Yufang Shi, Stan Gronthos, Songlin Wang, Songtao Shi Stem Cell Research & Therapy 2010, 1:5 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary SHED (stem cells from human exfoliated deciduous teeth) transplantation was used to treat systemic lupus erythematosus (SLE) in a mouse model, suggesting SHED are a feasible stem cell source for treating immune disorders.
	Research Switching of mesodermal and endodermal properties in hTERT-modified and expanded fetal human pancreatic progenitor cells Kang Cheng, Antonia Follenzi, Manju Surana, Norman Fleischer, Sanjeev Gupta Stem Cell Research & Therapy 2010, 1:6 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Limited replication capacity of pancreatic endocrine progenitor cells was overcome by the hTERT mechanism, facilitating efforts to control cell expansion without stopping differentiation needed to develop specific applications.
	Research Selection and reliability of internal reference genes for quantitative PCR verification of transcriptomics during the differentiation process of porcine adult mesenchymal stem cells Elisa Monaco, Massimo Bionaz, Alecsandra de Lima, Walter L Hurley, Juan J Loor, Matthew B Wheeler Stem Cell Research & Therapy 2010, 1:7 (30 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new protocol, combining microarray data with pair-wise gene analysis, identified novel reliable housekeeping genes for data normalization of adult porcine stem cells, and can be used in other similar experiments.
	Research A novel serum-free medium for the expansion of human mesenchymal stem cells Lucas G Chase, Uma Lakshmipathy, Luis A Solchaga, Mahendra S Rao, Mohan C Vemuri Stem Cell Research & Therapy 2010, 1:8 (2 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A novel serum-free mesenchymal stem cell culture medium could substitute ill-defined traditional culture medium for research applications – an important step in the development of a more clinically relevant culture system.