Stem Cell Research & Therapy | Volume 1 Issue 2

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	Volume 1 Issue 2
	Comment
	Commentary Tbx3: another important piece fitted into the pluripotent stem cell puzzle Melinda K Pirity, Andras Dinnyes Stem Cell Research & Therapy 2010, 1:12 (20 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Pirity and Dinnyes discuss the recent finding that T box gene 3 can improve the quality of induced pluripotent stem cells (iPSCs) and the potential implication this may have on improving iPSC technology.
	Commentary Mesenchymal stem cells immunosuppressive properties: is it specific to bone marrow-derived cells? Christian Jorgensen Stem Cell Research & Therapy 2010, 1:15 (8 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Findings that immunosuppressive properties are probably shared by all stromal cells including fibroblasts and stem cells isolated from exfoliated deciduous teeth may have clinical implications.
	Commentary Comment on basal epithelial stem cells as efficient targets for prostate cancer initiation Letitia Wong, Wade Bushman Stem Cell Research & Therapy 2010, 1:16 (8 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Wong and Bushman comment on a recent study showing cells with stem cell properties can undergo oncogenic transformation and produce prostate mouse lesions resembling different grades of human prostate cancer.
	Review
	Review Bone tissue engineering with human stem cells Darja Marolt, Miomir Knezevic, Gordana Vunjak-Novakovic Stem Cell Research & Therapy 2010, 1:10 (4 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Using human stem cells for bone tissue engineering may be a viable alternative to treating bone defects with autologous bone grafting or implanting bone substitute materials.
	Review Cancerous stem cells: deviant stem cells with cancer-causing misbehavior Julie M Chandler, Eric Lagasse Stem Cell Research & Therapy 2010, 1:13 (20 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cancerous stem cells, the result of changes in signaling pathways involved in stem cell survival and proliferation, show resistance to cancer therapies, and understanding their unique characteristics is key to targeting therapies towards them.
	Review Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells Jeffrey M Gimble, Farshid Guilak, Bruce A Bunnell Stem Cell Research & Therapy 2010, 1:19 (29 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gimble et al. review the clinical evidence using autologous adipose-derived cells that have been published in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines.
	Research
	Research Activin A expression regulates multipotency of mesenchymal progenitor cells Farida Djouad, Wesley M Jackson, Brent E Bobick, Sasa Janjanin, Yingjie Song, George TJ Huang, Rocky S Tuan Stem Cell Research & Therapy 2010, 1:11 (4 May 2010) Abstract \| Full text \| PDF \| PubMed \| F1000 \| Editor’s summary Activin A expression acts as a functional marker for multipotent mesenchymal progenitor cells, allowing for identification of the more desirable cell types for use in regenerative medicine.
	Research Expression of migration-related genes is progressively upregulated in murine Lineage^-Sca-1⁺c-Kit⁺population from the fetal to adult stages of development Jesús Ciriza, Marcos E García-Ojeda Stem Cell Research & Therapy 2010, 1:14 (20 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Migration-related genes are progressively upregulated in a murine Lineage-Sca-1+c-Kit+ cell population during their transition to the bone marrow microenvironment.
	Research Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: a longitudinal imaging study Johanna S Jackson, Jon P Golding, Catherine Chapon, William A Jones, Kishore K Bhakoo Stem Cell Research & Therapy 2010, 1:17 (15 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Research Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype Casey L Korecki, Juan M Taboas, Rocky S Tuan, James C Iatridis Stem Cell Research & Therapy 2010, 1:18 (16 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation towards nucleus pulposus-like phenotype with characteristics of the developing intervertebral disc (IVD), suggesting notochordal cells as a promising target for IVD repair.