Figure 6.

Stem cells, administered intravenously, home to an inflammatory lesion in the brain. (a) An LPS lesion was induced on the right corpus callosum, followed by intravenous administration of 50,000 IO-TAT-FITC-labelled eNCSCs (top row) or BMSCs (bottom row). Both cell types migrated to the LPS-lesion site (arrows) from the peripheral vasculature within 24 hours of administration. False-colored inserts show better the hypointense regions. (b) Both cells types migrated to the LPS lesion after intravenous injection. The IO-TAT-FITC signal demonstrated that the cells had migrated to the lesioned brain area from the peripheral vasculature 24 hours after injection (arrows; first column). Some FITC signal was detected in IB4⁺ resident macrophages/microglia (arrows; second column; red). Similarly, limited differentiation into GFAP⁺ glia was seen (arrows; third column; red). Scale bars: 1 mm (b; IO-TAT-FITC), 20 μm (b; IB4, GFAP).