Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells
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* Corresponding author: Jeffrey M Gimble gimblejm@pbrc.edu
1 Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
2 Department of Orthopedics, Louisiana State University Health Science Center, 1542 Tulane Avenue, Box T6-7, New Orleans LA 70112, USA
3 Division of Orthopaedic Surgery, Department of Surgery, 375 Medical Sciences Research Building, DUMC Box 3093, Duke University Medical Center, Durham, NC 27710, USA
4 Tulane Center for Gene Therapy, Tulane University Health Sciences Center, J. Bennett Johnston Building, 1324 Tulane Avenue, SL-99, New Orleans, LA 70112-2699, USA
5 Tulane National Primate Research Center, 18703 Three Rivers Road, Covington, LA 70433-8915, USA
Stem Cell Research & Therapy 2010, 1:19 doi:10.1186/scrt19
Published: 29 June 2010Abstract
Adipose tissue is now recognized as an accessible, abundant, and reliable site for the isolation of adult stem cells suitable for tissue engineering and regenerative medicine applications. The past decade has witnessed an explosion of preclinical data relating to the isolation, characterization, cryopreservation, differentiation, and transplantation of freshly isolated stromal vascular fraction cells and adherent, culture-expanded, adipose-derived stromal/stem cells in vitro and in animal models. This body of work has provided evidence supporting clinical translational applications of adipose-derived cells in safety and efficacy trials. The present article reviews the case reports and phase I-III clinical evidence using autologous adipose-derived cells that have been published, to date, in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines. Future directions and challenges facing the field are discussed and evaluated.