Table 1 |
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|
Representative preclinical animal studies using adipose-derived stromal/stem cells and stromal vascular fraction cells |
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| Tissue type |
Defect |
Species |
References |
|
|
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| Adipose/soft tissue |
Fat pad generation |
Murine, rat, ovine |
[51-60] |
| Lipodystrophy |
Murine |
[48,61] |
|
| Burn/radiation trauma |
Murine |
[62-64] |
|
| Bone |
Critical sized defect |
||
| Craniofacial |
Murine, rat |
[65,66] |
|
| Long bone |
Murine |
[67] |
|
| Spinal fusion |
Rat |
[68,69] |
|
| Cardiac |
Myocardial infarction |
Murine, rat |
[42,43,70,71] |
| Central nervous system |
Vascular injury/stroke |
Murine, rat |
[44,46,72] |
| Spinal cord trauma |
Rat |
[47] |
|
| Multiple sclerosis |
Murine |
[33] |
|
| Gastrointestinal tract |
Crohn's disease/inflammatory bowel syndrome |
Murine |
[73] |
| Hematopoiesis |
Bone marrow transplantation |
Murine |
[74,75] |
| Joint |
Osteoarthritis |
Canine, caprine, equine |
[76-79] |
| Liver |
Acute toxicity/regeneration |
Murine |
[80-88] |
| Pancreas |
Type 1 diabetes mellitus |
Murine, rat |
[48,89,90] |
| Renal |
Acute ischemia |
Rat |
(JMG, unpublished) |
| Skin |
Wounds, burns |
Murine, porcine |
[62,64,91] |
| Tendon |
Tendonitis |
Equine |
[92] |
| Urinary bladder |
Incontinence |
Rat |
[93] |
| Vascular |
Hind limb ischemia |
Murine, rat |
[36,41,45] |
|
|
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|
Gimble et al. Stem Cell Research & Therapy 2010 1:19 doi:10.1186/scrt19 |
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