Stem Cell Research & Therapy | Volume 1 Issue 5

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	Volume 1 Issue 5
	Comment
	Commentary Matrix elasticity in vitro controls muscle stem cell fate in vivo Matthew Raab, Jae-Won Shin, Dennis E Discher Stem Cell Research & Therapy 2010, 1:38 (10 December 2010) Abstract \| Full text \| PDF \| PubMed
	Commentary Homing in on a biological joint replacement Farshid Guilak Stem Cell Research & Therapy 2010, 1:40 (14 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new study in the Lancet suggests tissue engineering may provide the means to regenerate an entire joint surface beyond a simple focal defect in articular cartilage.
	Review
	Review New concepts on the immune modulation mediated by mesenchymal stem cells Bruce A Bunnell, Aline M Betancourt, Deborah E Sullivan Stem Cell Research & Therapy 2010, 1:34 (11 November 2010) Abstract \| Full text \| PDF \| PubMed
	Review Stem cells for the treatment of neurodegenerative diseases Elise Dantuma, Stephanie Merchant, Kiminobu Sugaya Stem Cell Research & Therapy 2010, 1:37 (10 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The advancement of clinical application of stem cells for treating neurodegenerative diseases is building, but care needs to be taken moving forwards with extensive scrutiny of trial protocols.
	Review Role of Oct4 in maintaining and regaining stem cell pluripotency Guilai Shi, Ying Jin Stem Cell Research & Therapy 2010, 1:39 (14 December 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Oct4, a transcription factor highly expressed in pluripotent cells and silent in differentiated cells, exerts tight control over pluripotency regulator expression, with further investigation needed surrounding the underlying molecular mechanism.
	Research
	Research Von willebrand factor increases endothelial cell adhesiveness for human mesenchymal stem cells by activating p38 mitogen-activated protein kinase Irina A Potapova, Ira S Cohen, Sergey V Doronin Stem Cell Research & Therapy 2010, 1:35 (17 November 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In response to stress, endothelial cells release von Willebrand Factor, which regulates endothelial cell adhesiveness for mesenchymal stem cells via activation of p38 mitogen-activated protein kinase.
	Research Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption Tom N Grammatopoulos, Susan M Jones, Masami Yoshimura, Brian R Hoover, Mita Das, Evan Y Snyder, Gaynor A Larson, Nancy R Zahniser, Boris Tabakoff, W Michael Zawada Stem Cell Research & Therapy 2010, 1:36 (1 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ethanol consumption in mice is reduced by transplanting stem cells over-expressing the human dopamine transporter, representing proof of principle for using stem cells to explore the role of neurotransmitters
	Research Differential fate and functional outcome of lithium chloride primed adult neural progenitor cell transplants in a rat model of Huntington disease Elena M Vazey, Bronwen Connor Stem Cell Research & Therapy 2010, 1:41 (22 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In vitro priming of adult neural progenitor cells (NPCs) with lithium chloride may augment transplant efficiency and accelerate sensorimotor function outcome, suggest studies in a rat model of Huntington’s disease.