Table 2

Histologic scoring

Tendon parameter

Fetal-derived embryonic-like stem cell treated tendon

Placebo control treated tendon

Two-tailed P

Cell shape

1.0 (0.9 to 1.3)

2.0 (1.8 to 2.3)*

<0.0001

Cell density

1.0 (2.0 to 2.0)

2.75 (2.3 to 3.0)*

0.0002

Free hemorrhage

1.0 (0.9 to 1.7)

1.75 (1.1 to 2.4)

0.1

Neo-vascularization

2.0 (1.4 to 2.2)

2.0 (1.2 to 2.3)

0.7

Perivascular cuffing

1.5 (1.1 to 2.0)

1.0 (0.83 to 1.4)

0.1

Collagen linearity

2.0 (1.3 to 2.1)

2.75 (2.4 to 3.0)*

<0.0001

Collagen uniformity

2.0 (1.4 to 2.1)

3.0 (2.8 to 3.1)*

<0.0001

Polarized crimping

1.5 (1.2 to 2.1)

3.0 (2.7 to 3.3)*

<0.0001

Epitenon thickening

2.3 (2.0 to 2.6)

3.0 (2.6 to 3.5)*

0.0009

Cumulative Score

15.4 (12.6 to 17.8)

20.8 (19.0 to 23.0)*

<0.0001

Histologic scores for fetal-derived embryonic-like stem cell treated tendon and placebo control treated tendon reported as median (95% confidence interval). Significant differences between treatment groups are marked by an asterisk (two-tailed P < 0.05) and the two-tailed P-values are listed.

Watts et al. Stem Cell Research & Therapy 2011 2:4   doi:10.1186/scrt45