Stem Cell Research & Therapy | Volume 2 Issue 3

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	Volume 2 Issue 3
	Comment
	Editorial Stem Cell Research & Therapy marks its first anniversary Philippa Locke, Timothy O'Brien, Rocky S Tuan Stem Cell Research & Therapy 2011, 2:22 (6 May 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Editors-in-Chief select some highlights from the journal’s first year of publication, and look forward to the future.
	Commentary Youth is wasted on the young Marc S Penn, Martiza E Mayorga, Feng Dong Stem Cell Research & Therapy 2011, 2:24 (18 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In their commentary, Marc Penn and co-authors review recent results on mammalian heart regeneration, and relate these findings to strategies to prevent and treat cardiac dysfunction.
	Commentary Dedifferentiation rescues senescence of progeria cells but only while pluripotent Laura J Niedernhofer, Joseph C Glorioso, Paul D Robbins Stem Cell Research & Therapy 2011, 2:28 (1 June 2011) Abstract \| Full text \| PDF \| PubMed
	Commentary Epidermal stem cell dynamics Maya Sieber-Blum Stem Cell Research & Therapy 2011, 2:29 (29 June 2011) Abstract \| Full text \| PDF \| PubMed
	Review
	Review Mesenchymal stem cells for the treatment of systemic lupus erythematosus: is the cure for connective tissue diseases within connective tissue? Flavio A Carrion, Fernando E Figueroa Stem Cell Research & Therapy 2011, 2:23 (11 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells have been successfully applied in patients with severe treatment-refractory systemic lupus erythematosus in uncontrolled phase I and II trials suggesting larger randomized controlled trials should be performed.
	Review Amnion-derived stem cells: in quest of clinical applications Toshio Miki Stem Cell Research & Therapy 2011, 2:25 (19 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Miki introduces a model theory to explain why so many amnion-derived cells possess stem cell characteristics, and reviews the therapeutic applications and pluripotency of amniotic epithelial cells.
	Review The role of p21 in regulating mammalian regeneration Larry Arthur, Ellen Heber-Katz Stem Cell Research & Therapy 2011, 2:30 (29 June 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Larry Arthur and Ellen Heber-Katz review their recent results demonstrating p21 knockout can activate regenerative capacity in a mouse model and speculate on the role of p21 in regeneration.
	Research
	Research In silico tandem affinity purification refines an Oct4 interaction list Clara Cheong, Patricia Lon Ng, Rhonda Ponnampalam, Heng-Hang Tsai, Guillaume Bourque, Thomas Lufkin Stem Cell Research & Therapy 2011, 2:26 (13 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The authors find 33 potential interactors with Oct4, a master regulator of early mammalian development, indicating that the transcription factor is involved in catalytic activities beyond transcriptional regulation and chromosome remodelling.
	Research Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6 Svitlana Danchuk, Joni H Ylostalo, Fokhrul Hossain, Randy Sorge, Austin Ramsey, Ryan W Bonvillain, Joseph A Lasky, Bruce A Bunnell, David A Welsh, Darwin J Prockop, Deborah E Sullivan Stem Cell Research & Therapy 2011, 2:27 (13 May 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology \| Editor’s summary Therapy with human multipotent stromal cells isolated from bone marrow was able to significantly reduce acute lung injury in mice within 48 hours, paving the way for clinical trials.