Figure 5.

Sequence analysis confirms PKD1 mutation in autosomal-dominant polycystic kidney disease-specific induced pluripotent stem cells. Autosomal-dominant polycystic kidney disease (ADPKD) patient DNA and ADPKD- induced pluripotent stem (iPS) cell DNA were analyzed by sequencing analysis. Sequence of exon 41 of PKD1 showing the 11,525G > A change resulting in W3842X in the ADPKD-iPS cells (center) and the patient's germline DNA (top) but not in the Wilms tumor (WT)-iPS cells (bottom).