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Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome

Xiaoning Mou1,2, Yuanbo Wu3,6, Henghua Cao1, Qingzhang Meng1, Qihui Wang1,2, Chengchao Sun6, Shengshou Hu3, Yue Ma1* and Hao Zhang3,4,5*

1 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China

2 Graduate University of the Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China

3 Key Laboratory for Cardiac Regeneration Medicine, Ministry of Health, Fuwai Hospital, 167 Belishi Road, Beijing 100037, China

4 State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 167 Belishi Road, Beijing 100037, China

5 Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences, 167 Belishi Road, Beijing 100037, China

6 Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital of Wenzhou Medical College, 2 Fuxue Lane, Wenzhou 325000, China

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Stem Cell Research & Therapy 2012, 3:14 doi:10.1186/scrt105

Published: 18 April 2012

Additional files

Additional file 1:

Supplementary Table 1. 18 short tandem repeats profiles of parental HDFs, iPSCs-DS, and hESCs-H7.

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Additional file 2:

Supplementary Table 2. Primers used for PCR, RT-PCR, and quantitative RT-PCR.

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