The reprogramming cells show a similar morphology to hESCs. (A) One induced pluripotent stem cell (iPSC) line derived from a Down syndrome (DS) patient with translocation (DS/translocation). Morphology of the parental human dermal fibroblasts (HDFs; left), iPSC1 (colony no.1 reprogrammed from HDFs-DS/translocation) before picking the colony (middle), and at passage 8 (right). (B) Two iPSC lines derived from a DS patient with trisomy 21 (DS/trisomy 21). Morphology of the parental HDFs (left), iPSCs 2 (Colony No. 2 reprogrammed from HDFs-DS/trisomy 21) and iPSC4 (Colony No. 4 reprogrammed from HDFs-DS/trisomy 21) before picking the colonies (middle), and at passage 5 (right). Scale bars, 100 μm.
Mou et al. Stem Cell Research & Therapy 2012 3:14 doi:10.1186/scrt105