The induced pluripotent stem cells (iPSCs-DSs) have a methylation status similar to that of hESCs. The methylation status of the endogenous OCT4 promoter in iPSCs-DS and parental human dermal fibroblasts was analyzed with bisulfite sequencing. Open circles indicate unmethylated CpGs, and solid circles indicate methylated CpGs.
Mou et al. Stem Cell Research & Therapy 2012 3:14 doi:10.1186/scrt105