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Volume 4 Issue 1
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Comment |
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Conversion of pericytes to neurons: a new guest at the reprogramming convention
Emmanuel Nivet, Ignacio Sancho-Martinez, Juan Izpisua Belmonte Stem Cell Research & Therapy 2013, 4:2 (11 January 2013)
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Editor’s summary
Juan Carlos Izpisua Belmonte comments on a recent article demonstrating pericytes can be converted into functional neurons and discusses their potential for treatment of central nervous system injuries or neurodegenerative processes. |
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Among mesenchymal stem cells: for the best therapy after ischemic stroke
Yuka Ikegame Stem Cell Research & Therapy 2013, 4:9 (31 January 2013)
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The effectiveness of stem cell therapies on health-related quality of life and life expectancy in comparison with conventional supportive medical treatment in patients suffering from end-stage liver disease
Adeeb M AlZoubi, Farah Khalifeh Stem Cell Research & Therapy 2013, 4:16 (25 February 2013)
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Adipose-derived stem cells weigh in as novel therapeutics for acute lung injury
Kushagra Gupta, Anja Hergrueter, Caroline A Owen Stem Cell Research & Therapy 2013, 4:19 (28 February 2013)
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Review |
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Return of results in translational iPS cell research: considerations for donor informed consent
Geoffrey P Lomax, Kelly A Shepard Stem Cell Research & Therapy 2013, 4:6 (21 January 2013)
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Editor’s summary
Lomax and Shepherd review the CIRM’s recommendations on informing tissue donors in disease-specific induced pluripotent stem (iPS) cell research, including gaining consent to recontact donors in the event of significant new findings. |
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Vascular tissue engineering: biodegradable scaffold platforms to promote angiogenesis
Janna V Serbo, Sharon Gerecht Stem Cell Research & Therapy 2013, 4:8 (24 January 2013)
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Editor’s summary
As part of the Physical influences on stem cells series, Serbo and Gerecht discuss the use of biodegradable scaffolds to control vascular network formation and promote angiogenesis in damaged tissue. |
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Mechanical control of tissue-engineered bone
Ben P Hung, Daphne L Hutton, Warren L Grayson Stem Cell Research & Therapy 2013, 4:10 (31 January 2013)
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Editor’s summary
Warren Grayson and colleagues review the use of mechanical forces to enhance osteogenesis in bone tissue engineering, based on knowledge obtained from mechanobiology studies of native bone. |
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Topological and electrical control of cardiac differentiation and assembly
Nimalan Thavandiran, Sara S Nunes, Yun Xiao, Milica Radisic Stem Cell Research & Therapy 2013, 4:14 (14 February 2013)
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Editor’s summary
Milica Radisic and colleagues review the use of engineered surface topology and electrical control in directing the cardiac differentiation of stem cells and the production of engineered heart tissue. |
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Cancer stem cell contribution to glioblastoma invasiveness
Barbara Ortensi, Matteo Setti, Daniela Osti, Giuliana Pelicci Stem Cell Research & Therapy 2013, 4:18 (28 February 2013)
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Editor’s summary
Pelicci and colleagues review the contribution of cancer stem cells (CSCs) to glioblastoma invasiveness and the role of epithelial-to-mesenchymal transition-associated factors, including double cortin and microRNAs. |
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Research |
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A new platelet cryoprecipitate glue promoting bone formation after ectopic mesenchymal stromal cell-loaded biomaterial implantation in nude mice
Marina Trouillas, Marie Prat, Christelle Doucet, Isabelle Ernou, Corinne Laplace-Builhé, Patrick Blancard, Xavier Holy, Jean-Jacques Lataillade Stem Cell Research & Therapy 2013, 4:1 (4 January 2013)
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Editor’s summary
Mesenchymal stem cells embedded in a platelet glue obtained from cryoprecipitation of apheresis platelet products showed enhanced in vitro proliferation and osteoblastic differentiation, and in vivo bone formation, without osteogenic pre-induction. |
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Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133+ ABCG2+CXCR4+ mesenchymal stem cells: development of autologous cell-based therapeutics for traumatic brain injury
Joan E Nichols, Jean A Niles, Douglas DeWitt, Donald Prough, Margaret Parsley, Stephanie Vega, Andrea Cantu, Eric Lee, Joaquin Cortiella Stem Cell Research & Therapy 2013, 4:3 (6 January 2013)
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Editor’s summary
A population of mesenchymal stem cells which can be reliably isolated from peripheral blood have potential for the treatment of traumatic brain injury and neurodegenerative disorders. |
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Myostatin genetic inactivation inhibits myogenesis by muscle-derived stem cells in vitro but not when implanted in the mdx mouse muscle
James Tsao, Dolores A Vernet, Robert Gelfand, Istvan Kovanecz, Gaby Nolazco, Kevin W Bruhn, Nestor F Gonzalez-Cadavid Stem Cell Research & Therapy 2013, 4:4 (7 January 2013)
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Editor’s summary
Inactivation of myostatin in muscle-derived stem cells (MDSC) blocks myotube formation in vitro, however the cells regain their myogenic capacity on implantation in a mouse model of Duchenne muscular dystrophy. |
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High targeted migration of human mesenchymal stem cells grown in hypoxia is associated with enhanced activation of RhoA
Grigory Vertelov, Ludmila Kharazi, M G Muralidhar, Givon Sanati, Timothy Tankovich, Alex Kharazi Stem Cell Research & Therapy 2013, 4:5 (7 January 2013)
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Editor’s summary
Human mesenchymal stem cells (hMSCs) grown in hypoxic conditions show high directional migration associated with increased sensitivity to RhoA, which may increase their therapeutic potential compared to normoxic cells. |
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Overexpression of Bcl-2 promotes survival and differentiation of neuroepithelial stem cells after transplantation into rat aganglionic colon
Wei Liu, Weiming Yue, Rongde Wu Stem Cell Research & Therapy 2013, 4:7 (16 January 2013)
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Editor’s summary
Genetically-modifying neural epithelial stem cells (NESCs) to over express the anti-apoptotic gene Bcl-2 enhances both their survival and neuronal differentiation on transplantation into aganglionic colon, potentially improving cell therapy for gastrointestinal disorders. |
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Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke
María Gutiérrez-Fernández, Berta Rodríguez-Frutos, Jaime Ramos-Cejudo, M Teresa Vallejo-Cremades, Blanca Fuentes, Sebastián Cerdán, Exuperio Díez-Tejedor Stem Cell Research & Therapy 2013, 4:11 (28 January 2013)
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Editor’s summary
Rats treated intravenously with bone marrow- or adipose-derived mesenchymal stem cells after experimental ischemic stroke showed improvements in brain and nerve repair, and ability to complete behavioural tasks. |
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Reciprocal interactions of mouse bone marrow-derived mesenchymal stem cells and BV2 microglia after lipopolysaccharide stimulation
Zul'atfi Rahmat, Shinsmon Jose, Rajesh Ramasamy, Sharmili Vidyadaran Stem Cell Research & Therapy 2013, 4:12 (28 January 2013)
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Editor’s summary
Mesenchymal stem cells (MSC) interact in a multifaceted manner with microglia, and their capability to adapt and regulate their specific cellular environment demonstrates their potential for immunomodulatory therapy. |
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Comparison of the therapeutic effects of human and mouse adipose-derived stem cells in a murine model of lipopolysaccharide-induced acute lung injury
Shijia Zhang, Svitlana D Danchuk, Kathleen MP Imhof, Julie A Semon, Brittni A Scruggs, Ryan W Bonvillain, Amy L Strong, Jeffrey M Gimble, Aline M Betancourt, Deborah E Sullivan, Bruce A Bunnell Stem Cell Research & Therapy 2013, 4:13 (29 January 2013)
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Editor’s summary
Anti-inflammatory effects of both human and mouse adipose-derived stem cells (ASC) in the lipopolysaccharide-induced acute lung injury (ALI) mouse model suggest ASC may have clinical potential in ALI. |
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BAY11 enhances OCT4 synthetic mRNA expression in adult human skin cells
Jason P Awe, Agustin Crespo, You Li, Megerditch Kiledjian, James A Byrne Stem Cell Research & Therapy 2013, 4:15 (6 February 2013)
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Editor’s summary
The small molecule BAY-11 suppresses the innate immune response and enhances the expression of synthetic OCT4 mRNA after transfection into adult human skin cells, with multiple potential research and therapeutic applications. |
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Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro
Laura Kyllönen, Suvi Haimi, Bettina Mannerström, Heini Huhtala, Kristiina M Rajala, Heli Skottman, George K Sándor, Susanna Miettinen Stem Cell Research & Therapy 2013, 4:17 (15 February 2013)
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Editor’s summary
Lower concentrations of dexamethasone and higher concentrations of L-ascorbic acid 2-phosphate should be used for the in vitro osteogenic differentiation of human adipose stem cells. |
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Identification of mouse colony-forming endothelial progenitor cells for postnatal neovascularization: a novel insight highlighted by new mouse colony-forming assay
Shizu Tsukada, Sang-Mo Kwon, Takenori Matsuda, Seok-Yun Jung, Jun-Hee Lee, Sang-Hun Lee, Haruchika Masuda, Takayuki Asahara Stem Cell Research & Therapy 2013, 4:20 (28 February 2013)
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