Stem Cell Research & Therapy

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		Research A comparison of the efficacy of transplantation of bone marrow-derived mesenchymal stem cells and unrestricted somatic stem cells on outcome after acute myocardial infarction Aidan Flynn, Xizhe Chen, Enda O'Connell, Timothy O'Brien Stem Cell Research & Therapy 2012, 3:36 (13 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The administration of guided unrestricted somatic stem cells had a moderately beneficial effect on cardiac function in a rat model of acute myocardial infarction, showing greater benefit than mesenchymal stem cells.
		Review Induced pluripotent stem cell technology for disease modeling and drug screening with emphasis on lysosomal storage diseases Hsiang-Po Huang, Ching-Yu Chuang, Hung-Chih Kuo Stem Cell Research & Therapy 2012, 3:34 (28 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hung-Chih Kuo and colleagues review recent advances in the use of induced pluripotent stem cells (iPSCs) for disease modelling and drug screening in lysosomal storage diseases (LSDs).
		Research Adipose stem cells can secrete angiogenic factors that inhibit hyaline cartilage regeneration Christopher SD Lee, Olivia A Burnsed, Vineeth Raghuram, Jonathan Kalisvaart, Barbara D Boyan, Zvi Schwartz Stem Cell Research & Therapy 2012, 3:35 (24 August 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary Adipose stem cells (ASCs) secrete factors that can inhibit cartilage regeneration, and must be pre-treated or modified to reduce these effects before they may be used as a therapy to repair cartilage.
		Review Therapeutic revascularisation of ischaemic tissue: the opportunities and challenges for therapy using vascular stem/progenitor cells Christina L O'Neill, Michelle T O'Doherty, Sarah EJ Wilson, Amer A Rana, Claire E Hirst, Alan W Stitt, Reinhold J Medina Stem Cell Research & Therapy 2012, 3:31 (16 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Reinhold Medina and colleagues examine the clinical potential of stem and progenitor cells to regenerate damaged vasculature and restore blood flow to ischemic tissues, focusing on endothelial progenitor cells.
		Research Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice Maik MA Worlitzer, Eva C Bunk, Kathrin Hemmer, Jens C Schwamborn Stem Cell Research & Therapy 2012, 3:33 (14 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Anti-inflammatory treatment activates adult neural stem cells leading to regenerative oligodendrogenesis in a parkinsonian mouse model, providing further evidence that controlling neuroinflammation is important in clinical approaches on Parkinson's disease.
		Commentary Heart bailout by cell therapy: introducing an acceptable test for comparing cell accountability Paolo Madeddu Stem Cell Research & Therapy 2012, 3:32 (14 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cell therapy for cardiovascular disease holds a lot of promise, but results in clinical trials have been disappointing; Paolo Madeddu discusses the need to identify appropriate cell types for promoting angiogenesis.
		Research Genetic background affects induced pluripotent stem cell generation Lauren V Schnabel, Christian M Abratte, John C Schimenti, Teresa L Southard, Lisa A Fortier Stem Cell Research & Therapy 2012, 3:30 (3 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genetic background affects both the efficiency of induced pluripotent stem cell (iPSC) generation and the pluripotent stability of cells during the later stages of reprogramming.
		Research Human foreskin fibroblast produces interleukin-6 to support derivation and self-renewal of mouse embryonic stem cells Yu Ma, Junjie Gu, Chunliang Li, Xiaoyuan Wei, Fan Tang, Guilai Shi, Jing Jiang, Ying Kuang, Jinsong Li, Zhugang Wang, Xin Xie, Ying Jin Stem Cell Research & Therapy 2012, 3:29 (31 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Human foreskin fibroblasts (HFF) produce interleukin-6 to support the derivation and maintenance of mouse embryonic stem cell (ESC) lines, providing a convenient, efficient and inexpensive ESC culture system.
		Review Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia Aaron Liew, Timothy O'Brien Stem Cell Research & Therapy 2012, 3:28 (30 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Aaron Liew and Timothy O'Brien discuss the potential of mesenchymal stem cell (MSC)-based therapy for critical limb ischemia (CLI), including results in animal models and early-phase human trial data.
		Editorial Stem cells and regenerative medicine Mahendra Rao Stem Cell Research & Therapy 2012, 3:27 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mahendra Rao introduces a new series on clinical applications of stem cells, discussing the progress made in taking stem cells from the bench to the bedside and the challenges remaining.
		Review The Aastrom experience Ronnda L Bartel, Caryn Cramer, Kelly Ledford, Amy Longcore, Christopher Parrish, Theresa Stern, Sharon Watling, Frank Zeigler Stem Cell Research & Therapy 2012, 3:26 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ronnda Bartel and colleagues describe their experience manufacturing an autologous differentiated cell product for the treatment of critical limb ischemia.
		Review Mesenchymal stem cells for cartilage repair in osteoarthritis Pawan K Gupta, Anjan K Das, Anoop Chullikana, Anish S Majumdar Stem Cell Research & Therapy 2012, 3:25 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The use of bone marrow stromal cells for cartilage repair and their therapeutic potential in osteoarthritis is discussed by Anish Majumdar and colleagues.
		Review Stem cell therapy for the spinal cord Eleanor M Donnelly, Jason Lamanna, Nicholas M Boulis Stem Cell Research & Therapy 2012, 3:24 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Nicholas Boulis and colleagues review clinical trials of stem cell transplantation into the spinal cord focusing on motor neuron diseases and spinal cord injury and discuss the optimization of delivery methods.
		Research Systematic assessment in an animal model of the angiogenic potential of different human cell sources for therapeutic revascularization G Robin Barclay, Olga Tura, Kay Samuel, Patrick WF Hadoke, Nicholas L Mills, David E Newby, Marc L Turner Stem Cell Research & Therapy 2012, 3:23 (3 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Hematopoietic progenitor cell (HPC) therapy for vascular regeneration works predominantly due to indirect proangiogenic effects rather than direct incorporation of endothelial progenitor cells, which are very rare in HPC sources.
		Research SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells Jagadeesh K Venkatesan, Myriam Ekici, Henning Madry, Gertrud Schmitt, Dieter Kohn, Magali Cucchiarini Stem Cell Research & Therapy 2012, 3:22 (28 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Transfer of SOX9 via replication-defective recombinant adeno-associated virus (rAAV) vector enhances the chondrogenic potential of human mesenchymal stem cells, with potential for future therapeutic applications to restore articular cartilage defects.
		Review Mesenchymal stem cell therapy for attenuation of scar formation during wound healing Wesley M Jackson, Leon J Nesti, Rocky S Tuan Stem Cell Research & Therapy 2012, 3:20 (31 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Editor-in-Chief Rocky Tuan and colleagues review the use of mesenchymal stem cells (MSCs) to promote scar-less wound healing, including the mechanisms by which they can limit tissue fibrosis.
		Research Characterization of lung stem cell niches in a mouse model of bleomycin-induced fibrosis Ena Banerjee, William Henderson Stem Cell Research & Therapy 2012, 3:21 (29 May 2012) Abstract \| Full text \| PDF \| PubMed
		Commentary Can a young muscle's stem cell secretome prolong our lives? Karl JA McCullagh Stem Cell Research & Therapy 2012, 3:19 (28 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Karl McCullagh comments on recent findings that a population of muscle stem cells are able to prolong life in a mouse model of premature ageing.
		Review Strategies for enrichment and selection of stem cell-derived tissue precursors Harold S Bernstein, William C Hyun Stem Cell Research & Therapy 2012, 3:17 (10 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bernstein and Hyun review strategies used to direct tissue-specific differentiation of embryonic stem cells (ESCs), and methods for the identification and selection of tissue-specific precursors for scientific study and clinical use.
		Research The secretome of stem cells isolated from the adipose tissue and Wharton jelly acts differently on central nervous system derived cell populations Carlos A Ribeiro, Joana S Fraga, Mário Grãos, Nuno M Neves, Rui L Reis, Jeffrey M Gimble, Nuno Sousa, António J Salgado Stem Cell Research & Therapy 2012, 3:18 (2 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The secretome of human umbilical cord perivascular cells (HUPVCs) and adipose tissue-derived stem cells differ, with HUPVC conditioned media able to promote neuronal survival and differentiation without exogenous supplement.
		Editorial Stem Cell Research & Therapy in 2012 Philippa Locke, Rocky S Tuan, Timothy O'Brien Stem Cell Research & Therapy 2012, 3:16 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Commentary Colonizing the heart from the epicardial side Nenad Bursac Stem Cell Research & Therapy 2012, 3:15 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nenad Bursac comments on recent research describing a distinct population of epicardium-derived mesenchymal stem cells residing in a perivascular niche of the heart with a broad multilineage potential, and considers future applications.
		Review Orthopaedic applications of nanoparticle-based stem cell therapies Ian Wimpenny, Hareklea Markides, Alicia J El Haj Stem Cell Research & Therapy 2012, 3:13 (19 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alicia El Haj and colleagues review recent research on the applications of iron-oxide-based magnetic nanoparticles to improve how stem cells are controlled, monitored and targeted to sites of repair.
		Research Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome Xiaoning Mou, Yuanbo Wu, Henghua Cao, Qingzhang Meng, Qihui Wang, Chengchao Sun, Shengshou Hu, Yue Ma, Hao Zhang Stem Cell Research & Therapy 2012, 3:14 (18 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The derivation of induced pluripotent stem cells (iPSCs) from two patients with different karyotypes of Down syndrome offers opportunities for disease modeling, drug discovery and potential future cell replacement therapies.
		Review Progress on stem cell research towards the treatment of Parkinson's disease Stuart AJ Gibson, Guo-Dong Gao, Katya McDonagh, Sanbing Shen Stem Cell Research & Therapy 2012, 3:11 (3 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sanbing Shen and colleagues provide an overview of recent progress towards a combined approach of drugs, cell replacement, and gene therapy to halt disease progression and improve treatment of Parkinson's disease.

	All
		Research A comparison of the efficacy of transplantation of bone marrow-derived mesenchymal stem cells and unrestricted somatic stem cells on outcome after acute myocardial infarction Aidan Flynn, Xizhe Chen, Enda O'Connell, Timothy O'Brien Stem Cell Research & Therapy 2012, 3:36 (13 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The administration of guided unrestricted somatic stem cells had a moderately beneficial effect on cardiac function in a rat model of acute myocardial infarction, showing greater benefit than mesenchymal stem cells.
		Review Induced pluripotent stem cell technology for disease modeling and drug screening with emphasis on lysosomal storage diseases Hsiang-Po Huang, Ching-Yu Chuang, Hung-Chih Kuo Stem Cell Research & Therapy 2012, 3:34 (28 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hung-Chih Kuo and colleagues review recent advances in the use of induced pluripotent stem cells (iPSCs) for disease modelling and drug screening in lysosomal storage diseases (LSDs).
		Research Adipose stem cells can secrete angiogenic factors that inhibit hyaline cartilage regeneration Christopher SD Lee, Olivia A Burnsed, Vineeth Raghuram, Jonathan Kalisvaart, Barbara D Boyan, Zvi Schwartz Stem Cell Research & Therapy 2012, 3:35 (24 August 2012) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary Adipose stem cells (ASCs) secrete factors that can inhibit cartilage regeneration, and must be pre-treated or modified to reduce these effects before they may be used as a therapy to repair cartilage.
		Review Therapeutic revascularisation of ischaemic tissue: the opportunities and challenges for therapy using vascular stem/progenitor cells Christina L O'Neill, Michelle T O'Doherty, Sarah EJ Wilson, Amer A Rana, Claire E Hirst, Alan W Stitt, Reinhold J Medina Stem Cell Research & Therapy 2012, 3:31 (16 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Reinhold Medina and colleagues examine the clinical potential of stem and progenitor cells to regenerate damaged vasculature and restore blood flow to ischemic tissues, focusing on endothelial progenitor cells.
		Research Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice Maik MA Worlitzer, Eva C Bunk, Kathrin Hemmer, Jens C Schwamborn Stem Cell Research & Therapy 2012, 3:33 (14 August 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Anti-inflammatory treatment activates adult neural stem cells leading to regenerative oligodendrogenesis in a parkinsonian mouse model, providing further evidence that controlling neuroinflammation is important in clinical approaches on Parkinson's disease.
		Commentary Heart bailout by cell therapy: introducing an acceptable test for comparing cell accountability Paolo Madeddu Stem Cell Research & Therapy 2012, 3:32 (14 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cell therapy for cardiovascular disease holds a lot of promise, but results in clinical trials have been disappointing; Paolo Madeddu discusses the need to identify appropriate cell types for promoting angiogenesis.
		Research Genetic background affects induced pluripotent stem cell generation Lauren V Schnabel, Christian M Abratte, John C Schimenti, Teresa L Southard, Lisa A Fortier Stem Cell Research & Therapy 2012, 3:30 (3 August 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genetic background affects both the efficiency of induced pluripotent stem cell (iPSC) generation and the pluripotent stability of cells during the later stages of reprogramming.
		Research Human foreskin fibroblast produces interleukin-6 to support derivation and self-renewal of mouse embryonic stem cells Yu Ma, Junjie Gu, Chunliang Li, Xiaoyuan Wei, Fan Tang, Guilai Shi, Jing Jiang, Ying Kuang, Jinsong Li, Zhugang Wang, Xin Xie, Ying Jin Stem Cell Research & Therapy 2012, 3:29 (31 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Human foreskin fibroblasts (HFF) produce interleukin-6 to support the derivation and maintenance of mouse embryonic stem cell (ESC) lines, providing a convenient, efficient and inexpensive ESC culture system.
		Review Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia Aaron Liew, Timothy O'Brien Stem Cell Research & Therapy 2012, 3:28 (30 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Aaron Liew and Timothy O'Brien discuss the potential of mesenchymal stem cell (MSC)-based therapy for critical limb ischemia (CLI), including results in animal models and early-phase human trial data.
		Editorial Stem cells and regenerative medicine Mahendra Rao Stem Cell Research & Therapy 2012, 3:27 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mahendra Rao introduces a new series on clinical applications of stem cells, discussing the progress made in taking stem cells from the bench to the bedside and the challenges remaining.
		Review The Aastrom experience Ronnda L Bartel, Caryn Cramer, Kelly Ledford, Amy Longcore, Christopher Parrish, Theresa Stern, Sharon Watling, Frank Zeigler Stem Cell Research & Therapy 2012, 3:26 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ronnda Bartel and colleagues describe their experience manufacturing an autologous differentiated cell product for the treatment of critical limb ischemia.
		Review Mesenchymal stem cells for cartilage repair in osteoarthritis Pawan K Gupta, Anjan K Das, Anoop Chullikana, Anish S Majumdar Stem Cell Research & Therapy 2012, 3:25 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The use of bone marrow stromal cells for cartilage repair and their therapeutic potential in osteoarthritis is discussed by Anish Majumdar and colleagues.
		Review Stem cell therapy for the spinal cord Eleanor M Donnelly, Jason Lamanna, Nicholas M Boulis Stem Cell Research & Therapy 2012, 3:24 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Nicholas Boulis and colleagues review clinical trials of stem cell transplantation into the spinal cord focusing on motor neuron diseases and spinal cord injury and discuss the optimization of delivery methods.
		Research Systematic assessment in an animal model of the angiogenic potential of different human cell sources for therapeutic revascularization G Robin Barclay, Olga Tura, Kay Samuel, Patrick WF Hadoke, Nicholas L Mills, David E Newby, Marc L Turner Stem Cell Research & Therapy 2012, 3:23 (3 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Hematopoietic progenitor cell (HPC) therapy for vascular regeneration works predominantly due to indirect proangiogenic effects rather than direct incorporation of endothelial progenitor cells, which are very rare in HPC sources.
		Research SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells Jagadeesh K Venkatesan, Myriam Ekici, Henning Madry, Gertrud Schmitt, Dieter Kohn, Magali Cucchiarini Stem Cell Research & Therapy 2012, 3:22 (28 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Transfer of SOX9 via replication-defective recombinant adeno-associated virus (rAAV) vector enhances the chondrogenic potential of human mesenchymal stem cells, with potential for future therapeutic applications to restore articular cartilage defects.
		Review Mesenchymal stem cell therapy for attenuation of scar formation during wound healing Wesley M Jackson, Leon J Nesti, Rocky S Tuan Stem Cell Research & Therapy 2012, 3:20 (31 May 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Editor-in-Chief Rocky Tuan and colleagues review the use of mesenchymal stem cells (MSCs) to promote scar-less wound healing, including the mechanisms by which they can limit tissue fibrosis.
		Research Characterization of lung stem cell niches in a mouse model of bleomycin-induced fibrosis Ena Banerjee, William Henderson Stem Cell Research & Therapy 2012, 3:21 (29 May 2012) Abstract \| Full text \| PDF \| PubMed
		Commentary Can a young muscle's stem cell secretome prolong our lives? Karl JA McCullagh Stem Cell Research & Therapy 2012, 3:19 (28 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Karl McCullagh comments on recent findings that a population of muscle stem cells are able to prolong life in a mouse model of premature ageing.
		Review Strategies for enrichment and selection of stem cell-derived tissue precursors Harold S Bernstein, William C Hyun Stem Cell Research & Therapy 2012, 3:17 (10 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bernstein and Hyun review strategies used to direct tissue-specific differentiation of embryonic stem cells (ESCs), and methods for the identification and selection of tissue-specific precursors for scientific study and clinical use.
		Research The secretome of stem cells isolated from the adipose tissue and Wharton jelly acts differently on central nervous system derived cell populations Carlos A Ribeiro, Joana S Fraga, Mário Grãos, Nuno M Neves, Rui L Reis, Jeffrey M Gimble, Nuno Sousa, António J Salgado Stem Cell Research & Therapy 2012, 3:18 (2 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The secretome of human umbilical cord perivascular cells (HUPVCs) and adipose tissue-derived stem cells differ, with HUPVC conditioned media able to promote neuronal survival and differentiation without exogenous supplement.
		Editorial Stem Cell Research & Therapy in 2012 Philippa Locke, Rocky S Tuan, Timothy O'Brien Stem Cell Research & Therapy 2012, 3:16 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
		Commentary Colonizing the heart from the epicardial side Nenad Bursac Stem Cell Research & Therapy 2012, 3:15 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nenad Bursac comments on recent research describing a distinct population of epicardium-derived mesenchymal stem cells residing in a perivascular niche of the heart with a broad multilineage potential, and considers future applications.
		Review Orthopaedic applications of nanoparticle-based stem cell therapies Ian Wimpenny, Hareklea Markides, Alicia J El Haj Stem Cell Research & Therapy 2012, 3:13 (19 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alicia El Haj and colleagues review recent research on the applications of iron-oxide-based magnetic nanoparticles to improve how stem cells are controlled, monitored and targeted to sites of repair.
		Research Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome Xiaoning Mou, Yuanbo Wu, Henghua Cao, Qingzhang Meng, Qihui Wang, Chengchao Sun, Shengshou Hu, Yue Ma, Hao Zhang Stem Cell Research & Therapy 2012, 3:14 (18 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The derivation of induced pluripotent stem cells (iPSCs) from two patients with different karyotypes of Down syndrome offers opportunities for disease modeling, drug discovery and potential future cell replacement therapies.
		Review Progress on stem cell research towards the treatment of Parkinson's disease Stuart AJ Gibson, Guo-Dong Gao, Katya McDonagh, Sanbing Shen Stem Cell Research & Therapy 2012, 3:11 (3 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sanbing Shen and colleagues provide an overview of recent progress towards a combined approach of drugs, cell replacement, and gene therapy to halt disease progression and improve treatment of Parkinson's disease.