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	1. 1087 Accesses	Research Generation of disease-specific induced pluripotent stem cells from patients with different karyotypes of Down syndrome Xiaoning Mou, Yuanbo Wu, Henghua Cao, Qingzhang Meng, Qihui Wang, Chengchao Sun, Shengshou Hu, Yue Ma, Hao Zhang Stem Cell Research & Therapy 2012, 3:14 (18 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The derivation of induced pluripotent stem cells (iPSCs) from two patients with different karyotypes of Down syndrome offers opportunities for disease modeling, drug discovery and potential future cell replacement therapies.
	2. 971 Accesses	Review Progress on stem cell research towards the treatment of Parkinson's disease Stuart AJ Gibson, Guo-Dong Gao, Katya McDonagh, Sanbing Shen Stem Cell Research & Therapy 2012, 3:11 (3 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sanbing Shen and colleagues provide an overview of recent progress towards a combined approach of drugs, cell replacement, and gene therapy to halt disease progression and improve treatment of Parkinson's disease.
	3. 750 Accesses	Review Orthopaedic applications of nanoparticle-based stem cell therapies Ian Wimpenny, Hareklea Markides, Alicia J El Haj Stem Cell Research & Therapy 2012, 3:13 (19 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Alicia El Haj and colleagues review recent research on the applications of iron-oxide-based magnetic nanoparticles to improve how stem cells are controlled, monitored and targeted to sites of repair.
	4. 699 Accesses	Research The secretome of stem cells isolated from the adipose tissue and Wharton's jelly acts differently on central nervous system-derived cell populations Carlos A Ribeiro, Joana S Fraga, Mario Graos, Nuno M Neves, Rui L Reis, Jeffrey M Gimble, Nuno Sousa, Antonio J Salgado Stem Cell Research & Therapy 2012, 3:18 (2 May 2012) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The secretome of human umbilical cord perivascular cells (HUPVCs) and adipose tissue-derived stem cells differ, with HUPVC conditioned media able to promote neuronal survival and differentiation without exogenous supplement.
	5. 563 Accesses	Review Dormancy in the stem cell niche Roberta Sottocornola, Cristina Lo Celso Stem Cell Research & Therapy 2012, 3:10 (19 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sottocornola and Lo Celso review recent findings on dormant hematopoietic stem cells, examining whether the mechanism of dormancy is common amongst regenerating tissues, and discuss implications for cancer therapy.
	6. 501 Accesses	Research Production and validation of a good manufacturing practice grade human fibroblast line for supporting human embryonic stem cell derivation and culture Nilendran Prathalingam, Linda Ferguson, Lesley Young, Georg Lietz, Rachel Oldershaw, Lyn Healy, Albert Craig, Helen Lister, Rakesh Binaykia, Radhika Sheth, Alison Murdoch, Mary Herbert Stem Cell Research & Therapy 2012, 3:12 (28 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The human fibroblast line Ncl1Fed1A, produced in compliance with good manufacturing practice (GMP) standards, has been qualified for derivation and maintenance of human embryonic stem cells (hESCs).
	7. 495 Accesses	Commentary Colonizing the heart from the epicardial side Nenad Bursac Stem Cell Research & Therapy 2012, 3:15 (30 April 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nenad Bursac comments on recent research describing a distinct population of epicardium-derived mesenchymal stem cells residing in a perivascular niche of the heart with a broad multilineage potential, and considers future applications.
	8. 447 Accesses	Review Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications Soufiane Ghannam, Carine Bouffi, Farida Djouad, Christian Jorgensen, Danièle Noël Stem Cell Research & Therapy 2010, 1:2 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ghannam et al discuss the targets and mechanisms of mesenchymal stem cell (MSC)-mediated immunosuppression, and the potential use of MSCs to modulate immune responses in a variety of autoimmune diseases.
	9. 445 Accesses	Research Hypoxia mediated isolation and expansion enhances the chondrogenic capacity of bone marrow mesenchymal stromal cells Adetola B Adesida, Aillette Mulet-Sierra, Nadr M Jomha Stem Cell Research & Therapy 2012, 3:9 (2 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hypoxia-mediated isolation and expansion increases the chondrogenic potential of bone marrow mesenchymal stromal cells (BMSCs) and may improve their clinical applications in cartilage repair.
	10. 416 Accesses	Editorial Stem Cell Research & Therapy in 2012 Philippa Locke, Rocky S Tuan, Timothy O'Brien Stem Cell Research & Therapy 2012, 3:16 (30 April 2012) Abstract \| Full text \| PDF \| PubMed
	11. 415 Accesses	Review Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells Tohru Sugawara, Koichiro Nishino, Akihiro Umezawa, Hidenori Akutsu Stem Cell Research & Therapy 2012, 3:8 (8 March 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hide Akutsu and colleagues review recent research on variation in induced pluripotent stem (iPS) cells, their ability to differentiate and the identity of the differentiated cells.
	12. 381 Accesses	Research Phenotypical and functional characteristics of mesenchymal stem cells from bone marrow: comparison of culture using different media supplemented with human platelet lysate or fetal bovine serum Nesrine Azouna, Faouzi Jenhani, Zohra Regaya, Lamia Berraeis, Tarek Othman, Elfi Ducrocq, Jorge Domenech Stem Cell Research & Therapy 2012, 3:6 (14 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells expanded in human platelet lysate supplemented media without fetal bovine serum (FBS) retain their phenotype and differentiation capacity, while an increased growth rate may allow for reduced culture time.
	13. 336 Accesses	Research A novel serum-free medium for the expansion of human mesenchymal stem cells Lucas G Chase, Uma Lakshmipathy, Luis A Solchaga, Mahendra S Rao, Mohan C Vemuri Stem Cell Research & Therapy 2010, 1:8 (2 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A novel serum-free mesenchymal stem cell culture medium could substitute ill-defined traditional culture medium for research applications – an important step in the development of a more clinically relevant culture system.
	14. 325 Accesses	Review Stem cell- and growth factor-based regenerative therapies for avascular necrosis of the femoral head Lars Rackwitz, Lars Eden, Stephan Reppenhagen, Johannes C Reichert, Franz Jakob, Heike Walles, Oliver Pullig, Rocky S Tuan, Maximilian Rudert, Ulrich Nöth Stem Cell Research & Therapy 2012, 3:7 (22 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ulrich Noth and colleagues review regenerative medicine approaches to treating avascular necrosis of the femoral head, a debilitating disease often leading to osteoarthritis and eventually hip replacement in young adults.
	15. 311 Accesses	Research Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells Seiga Ohmine, Allan B Dietz, Michael C Deeds, Katherine A Hartjes, David R Miller, Tayaramma Thatava, Toshie Sakuma, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:46 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hematopoietic progenitor cells and peripheral blood mononuclear cells could be ideal somatic cell sources for clinical-grade induced pluripotent stem cell (iPSC) derivation, allowing minimally invasive tissue procurement and rapid cellular reprogramming.
	16. 272 Accesses	Review Strategies for enrichment and selection of stem cell-derived tissue precursors Harold S Bernstein, William C Hyun Stem Cell Research & Therapy 2012, 3:17 (10 May 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bernstein and Hyun review strategies used to direct tissue-specific differentiation of embryonic stem cells (ESCs), and methods for the identification and selection of tissue-specific precursors for scientific study and clinical use.
	17. 257 Accesses	Review Bone tissue engineering with human stem cells Darja Marolt, Miomir Knezevic, Gordana Vunjak-Novakovic Stem Cell Research & Therapy 2010, 1:10 (4 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Using human stem cells for bone tissue engineering may be a viable alternative to treating bone defects with autologous bone grafting or implanting bone substitute materials.
	18. 249 Accesses	Research Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation Tayaramma Thatava, Adam S Armstrong, Josep De Lamo, Ramakrishna Edukulla, Yulia Khan, Toshie Sakuma, Seiga Ohmine, Jamie L Sundsbak, Peter C Harris, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:48 (6 December 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Disease-specific induced pluripotent stem cells (iPSCs) have been generated from kidney transplant recipients, providing opportunities to study patient-specific disease pathogenesis in vitro and demonstrating potential for autologous kidney replacement therapy.
	19. 224 Accesses	Review Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells Jeffrey M Gimble, Farshid Guilak, Bruce A Bunnell Stem Cell Research & Therapy 2010, 1:19 (29 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gimble et al. review the clinical evidence using autologous adipose-derived cells that have been published in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines.
	20. 223 Accesses	Review Mesenchymal stem cell effects on T-cell effector pathways Michelle M Duffy, Thomas Ritter, Rhodri Ceredig, Matthew D Griffin Stem Cell Research & Therapy 2011, 2:34 (11 August 2011) Abstract \| Full text \| PDF \| PubMed
	21. 216 Accesses	Review The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms Sara Morando, Tiziana Vigo, Marianna Esposito, Simona Casazza, Giovanni Novi, Maria Principato, Roberto Furlan, Antonio Uccelli Stem Cell Research & Therapy 2012, 3:3 (26 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Many studies have demonstrated that mesenchymal stem cells are effective in the treatment of experimental autoimmune encephalomyelitis (EAE) and may have potential as a therapeutic option in multiple sclerosis.
	22. 214 Accesses	Review Growth factor regulation of proliferation and survival of multipotential stromal cells Melanie Rodrigues, Linda G Griffith, Alan Wells Stem Cell Research & Therapy 2010, 1:32 (26 October 2010) Abstract \| Full text \| PDF \| PubMed
	23. 203 Accesses	Research Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype Casey L Korecki, Juan M Taboas, Rocky S Tuan, James C Iatridis Stem Cell Research & Therapy 2010, 1:18 (16 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation towards nucleus pulposus-like phenotype with characteristics of the developing intervertebral disc (IVD), suggesting notochordal cells as a promising target for IVD repair.
	24. 201 Accesses	Research Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6 Svitlana Danchuk, Joni H Ylostalo, Fokhrul Hossain, Randy Sorge, Austin Ramsey, Ryan W Bonvillain, Joseph A Lasky, Bruce A Bunnell, David A Welsh, Darwin J Prockop, Deborah E Sullivan Stem Cell Research & Therapy 2011, 2:27 (13 May 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Medicine \| F1000 Biology \| Editor’s summary Therapy with human multipotent stromal cells isolated from bone marrow was able to significantly reduce acute lung injury in mice within 48 hours, paving the way for clinical trials.
	25. 198 Accesses	Research Interleukin-1β and transforming growth factor-β cooperate to induce neurosphere formation and increase tumorigenicity of adherent LN-229 glioma cells Lei Wang, Ziyan Liu, Sivasai Balivada, Tej Shrestha, Stefan Bossmann, Marla Pyle, Loretta Pappan, Jishu Shi, Deryl Troyer Stem Cell Research & Therapy 2012, 3:5 (10 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Glioma cells that fail to self-renew in standard conditions can gain this ability after exposure to IL-1β and TGF-β suggesting targeting glioma stem cell-promoting cytokines may increase the efficacy of glioma therapies.