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	1. 1848 Accesses	Research The dual effect of mesenchymal stem cells on tumour growth and tumour angiogenesis Michelle Kéramidas, Florence de Fraipont, Anastassia Karageorgis, Anaïck Moisan, Virginie Persoons, Marie-Jeanne Richard, Jean-Luc Coll, Claire Rome Stem Cell Research & Therapy 2013, 4:41 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Injection of human mesenchymal stem cells into established tumors in mice slowed tumor growth, and this effect appeared to be due to changes in tumor angiogenesis.
	2. 1735 Accesses	Research SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells Jagadeesh K Venkatesan, Myriam Ekici, Henning Madry, Gertrud Schmitt, Dieter Kohn, Magali Cucchiarini Stem Cell Research & Therapy 2012, 3:22 (28 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Transfer of SOX9 via replication-defective recombinant adeno-associated virus (rAAV) vector enhances the chondrogenic potential of human mesenchymal stem cells, with potential for future therapeutic applications to restore articular cartilage defects.
	3. 1500 Accesses	Research Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro Ying Zhou, Huitao Xu, Wenrong Xu, Bingying Wang, Huiyi Wu, Yang Tao, Bin Zhang, Mei Wang, Fei Mao, Yongmin Yan, Shuo Gao, Hongbing Gu, Wei Zhu, Hui Qian Stem Cell Research & Therapy 2013, 4:34 (25 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Exosomes derived from human umbilical cord mesenchymal stem cells repair cisplatin-induced nephrotoxicity in vitro and in a rat model of acute kidney injury, reducing apoptosis and promoting cell proliferation.
	4. 1332 Accesses	Research Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: results of three sequential pilot studies Jessica M Quimby, Tracy L Webb, Lauren M Habenicht, Steven W Dow Stem Cell Research & Therapy 2013, 4:48 (30 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Intravenous administration of cryopreserved allogeneic adipose-derived mesenchymal stem cells in cats with chronic kidney disease resulted in significant adverse effects and no clinical improvement.
	5. 980 Accesses	Review Standardization of human stem cell pluripotency using bioinformatics Michael W Nestor, Scott A Noggle Stem Cell Research & Therapy 2013, 4:37 (25 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nestor and Noggle review approaches using bioinformatics and gene profiling to standardize pluripotency assays, one of the major hurdles in the development of high-throughput production of human stem cells for regenerative therapies.
	6. 948 Accesses	Research Phenotypical and functional characteristics of mesenchymal stem cells from bone marrow: comparison of culture using different media supplemented with human platelet lysate or fetal bovine serum Nesrine Azouna, Faouzi Jenhani, Zohra Regaya, Lamia Berraeis, Tarek Othman, Elfi Ducrocq, Jorge Domenech Stem Cell Research & Therapy 2012, 3:6 (14 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mesenchymal stem cells expanded in human platelet lysate supplemented media without fetal bovine serum (FBS) retain their phenotype and differentiation capacity, while an increased growth rate may allow for reduced culture time.
	7. 887 Accesses	Research Characterization of bone marrow derived mesenchymal stem cells in suspension Kentaro Akiyama, Yong-Ouk You, Takayoshi Yamaza, Chider Chen, Liang Tang, Yan Jin, Xiao-Dong Chen, Stan Gronthos, Songtao Shi Stem Cell Research & Therapy 2012, 3:40 (19 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Identification of a new subset of bone marrow mesenchymal stem cells (BMMSCs) with superior immunomodulatory properties that may be lost in the standard isolation assay could aid improvements in immunotherapy.
	8. 875 Accesses	Research Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke María Gutiérrez-Fernández, Berta Rodríguez-Frutos, Jaime Ramos-Cejudo, M Teresa Vallejo-Cremades, Blanca Fuentes, Sebastián Cerdán, Exuperio Díez-Tejedor Stem Cell Research & Therapy 2013, 4:11 (28 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rats treated intravenously with bone marrow- or adipose-derived mesenchymal stem cells after experimental ischemic stroke showed improvements in brain and nerve repair, and ability to complete behavioural tasks.
	9. 840 Accesses	Commentary The dual role of mesenchymal stem cells in tumor progression Célia Gomes Stem Cell Research & Therapy 2013, 4:42 (29 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Celia Gomes comments on research showing human mesenchymal stem cells (MSCs) slow tumor growth in established murine tumors, whereas MSC administration appears to increase growth in newly formed tumors.
	10. 834 Accesses	Commentary Regenerating the injured kidney with human umbilical cord mesenchymal stem cell-derived exosomes Akaitz Dorronsoro, Paul D Robbins Stem Cell Research & Therapy 2013, 4:39 (25 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Dorronsoro and Robbins comment on research demonstrating the potential clinical utility of stem cell-derived exosomes and discuss their possible benefits over stem cell transplantation, including ease of isolation and safety.
	11. 775 Accesses	Research The characteristic expression pattern of BMI-1 and SALL4 genes in placenta tissue and cord blood Shaohua Chen, Sichu Liu, Ling Xu, Lijian Yang, Zhenyi Jin, Yu Ma, Bo Li, Xiuli Wu, Jianchang Yang, Yupo Ma, Yangqiu Li Stem Cell Research & Therapy 2013, 4:49 (30 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Higher expression levels of the hematopoiesis-related genes SALL4 and BMI-1 in placental tissue compared with umbilical cord blood suggest it might be a good source for expansion of hematopoietic progenitor cells (HPCs).
	12. 718 Accesses	Research Umbilical cord blood-derived mesenchymal stem cells consist of a unique population of progenitors co-expressing mesenchymal stem cell and neuronal markers capable of instantaneous neuronal differentiation Mundackal S Divya, George E Roshin, Thulasi S Divya, Vazhanthodi Rasheed, Thankayyan R Santhoshkumar, Kandathil E Elizabeth, Jackson James, Radhakrishna M Pillai Stem Cell Research & Therapy 2012, 3:57 (19 December 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) include a unique population of cells expressing both MSC and neuronal progenitor markers, which are capable of instantaneous neuronal differentiation.
	13. 681 Accesses	Review Therapeutic implications of mesenchymal stem cells in acute lung injury/acute respiratory distress syndrome Yan-Yang Wang, Xiu-Zhong Li, Li-Bing Wang Stem Cell Research & Therapy 2013, 4:45 (2 May 2013) Abstract \| Full text \| PDF \| PubMed
	14. 625 Accesses	Review Pluripotent stem cells for Parkinson's disease: progress and challenges Xianmin Zeng, Larry A Couture Stem Cell Research & Therapy 2013, 4:25 (15 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Zeng and Couture discuss the potential of pluripotent stem cells for cell replacement therapy in Parkinson's disease and the requirements for their development for use in human clinical trials.
	15. 609 Accesses	Research Monitoring neurodegeneration in diabetes using adult neural stem cells derived from the olfactory bulb Ryo Hidaka, Masanao Machida, Shin Fujimaki, Kazuyuki Terashima, Makoto Asashima, Tomoko Kuwabara Stem Cell Research & Therapy 2013, 4:51 (14 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Adult neural stem cells extracted from the olfactory bulb of diabetic rats can be cultured in vitro and show similar gene expression profiles to hippocampal neural stem cells during diabetes progression.
	16. 605 Accesses	Research Endothelial microvascular networks affect gene expression profiles and osteogenic potential of tissue-engineered constructs Torbjorn O Pedersen, Anna L Blois, Zhe Xing, Ying Xue, Yang Sun, Anna Finne-Wistrand, Lars A Akslen, James B Lorens, Knut N Leknes, Inge Fristad, Kamal Mustafa Stem Cell Research & Therapy 2013, 4:52 (17 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Copolymer scaffolds can be prevascularized with endothelial cells (EC) and mesenchymal stem cells (MSC); seeding of MSC with or without EC increases the osteogenic potential of tissue-engineered constructs.
	17. 591 Accesses	Research Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment Lynsey Howard, Ruth M Mackenzie, Nikolay A Pchelintsev, Tony McBryan, John D McClure, Martin W McBride, Nicole M Kane, Peter D Adams, Graeme Milligan, Andrew H Baker Stem Cell Research & Therapy 2013, 4:36 (24 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Transcription factor FOXA2 is an early marker of mesoderm lineage commitment in human embryonic stem cells undergoing directed endothelial differentiation, potentially increasing cell yield for regenerative therapies in cardiovascular disease.
	18. 562 Accesses	Editorial Three years of Stem Cell Research & Therapy Philippa Locke, Timothy O’Brien, Rocky S Tuan Stem Cell Research & Therapy 2013, 4:46 (1 May 2013) Full text \| PDF \| PubMed
	19. 557 Accesses	Research Identification of p63⁺ keratinocyte progenitor cells in circulation and their matrix-directed differentiation to epithelial cells Renjith P Nair, Lissy K Krishnan Stem Cell Research & Therapy 2013, 4:38 (11 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A specially designed matrix with potential applications in skin tissue engineering enables the selection of p63⁺ keratinocyte progenitor cells (KPC) from peripheral blood mononuclear cells, and favours their differentiation into epithelial cells.
	20. 559 Accesses	Research Vasculogenesis of decidua side population cells of first-trimester pregnancy Qiushi Wang, Licong Shen, Wei Huang, Yong Song, Li Xiao, Wenming Xu, Ying Liu Stem Cell Research & Therapy 2013, 4:50 (7 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Human first-trimester decidua side population cells can differentiate into endothelial cells and form tube-like structures in vitro and may induce vasculogenesis in vivo in the ischemic limb nude mouse model.
	21. 543 Accesses	Review Growth factor regulation of proliferation and survival of multipotential stromal cells Melanie Rodrigues, Linda G Griffith, Alan Wells Stem Cell Research & Therapy 2010, 1:32 (26 October 2010) Abstract \| Full text \| PDF \| PubMed
	22. 538 Accesses	Review Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications Soufiane Ghannam, Carine Bouffi, Farida Djouad, Christian Jorgensen, Danièle Noël Stem Cell Research & Therapy 2010, 1:2 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ghannam et al discuss the targets and mechanisms of mesenchymal stem cell (MSC)-mediated immunosuppression, and the potential use of MSCs to modulate immune responses in a variety of autoimmune diseases.
	23. 513 Accesses	Review Age-associated changes in the ecological niche: implications for mesenchymal stem cell aging Faizal Z Asumda Stem Cell Research & Therapy 2013, 4:47 (14 May 2013) Abstract \| Full text \| PDF \| PubMed
	24. 500 Accesses	Research Oxidative stress-induced Notch1 signaling promotes cardiogenic gene expression in mesenchymal stem cells Archana V Boopathy, Karl D Pendergrass, Pao Lin Che, Young-Sup Yoon, Michael E Davis Stem Cell Research & Therapy 2013, 4:43 (18 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Oxidative stress may promote cardiac differentiation of adult stem or progenitor cells by increasing Notch1 signalling, potentially improving cell-based therapy for cardiac repair and regeneration.
	25. 491 Accesses	Research Human amniotic fluid- and dental pulp-derived stem cells seeded into collagen scaffold repair critical size bone defects promoting vascularization Tullia Maraldi, Massimo Riccio, Alessandra Pisciotta, Manuela Zavatti, Gianluca Carnevale, Francesca Beretti, Giovanni B La Sala, Antonella Motta, Anto De Pol Stem Cell Research & Therapy 2013, 4:53 (21 May 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Dental pulp- and amniotic fluid-derived stem cells seeded into collagen scaffolds repair large cranial bone defects in a rat model and are involved in vascularization of the implant.