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	1. 569 Accesses	Research Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells Seiga Ohmine, Allan B Dietz, Michael C Deeds, Katherine A Hartjes, David R Miller, Tayaramma Thatava, Toshie Sakuma, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:46 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hematopoietic progenitor cells and peripheral blood mononuclear cells could be ideal somatic cell sources for clinical-grade induced pluripotent stem cell (iPSC) derivation, allowing minimally invasive tissue procurement and rapid cellular reprogramming.
	2. 562 Accesses	Research Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation Tayaramma Thatava, Adam S Armstrong, Josep De Lamo, Ramakrishna Edukulla, Yulia Khan, Toshie Sakuma, Seiga Ohmine, Jamie L Sundsbak, Peter C Harris, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:48 (6 December 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Disease-specific induced pluripotent stem cells (iPSCs) have been generated from kidney transplant recipients, providing opportunities to study patient-specific disease pathogenesis in vitro and demonstrating potential for autologous kidney replacement therapy.
	3. 556 Accesses	Commentary When one cell is enough Rhodri Ceredig Stem Cell Research & Therapy 2012, 3:1 (13 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Rhodri Ceredig discusses a significant advance in our understanding of human hematopoiesis.
	4. 526 Accesses	Review Bone marrow mononuclear cells and acute myocardial infarction Samer Arnous, Abdul Mozid, John Martin, Anthony Mathur Stem Cell Research & Therapy 2012, 3:2 (17 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The use of bone-marrow derived mononuclear cells in cardiac repair after acute myocardial infarction, a leading cause of death and disability, is reviewed by Anthony Mathur and colleagues.
	5. 523 Accesses	Research MicroRNA profiling reveals age dependent differential expression of nuclear factor kappa B and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells cells Amitabh C Pandey, Julie Semon, Deepak Kaushal, Regina P O'Sullivan, Julie Glowacki, Jeffery M Gimble, Bruce A Bunnell Stem Cell Research & Therapy 2011, 2:49 (14 December 2011) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Differential expression of microRNAs is an integral component of biological aging in mesenchymal stem cells, regulating gene expression related to a variety of functions including cellular proliferation and inflammation.
	6. 520 Accesses	Review Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications Soufiane Ghannam, Carine Bouffi, Farida Djouad, Christian Jorgensen, Danièle Noël Stem Cell Research & Therapy 2010, 1:2 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ghannam et al discuss the targets and mechanisms of mesenchymal stem cell (MSC)-mediated immunosuppression, and the potential use of MSCs to modulate immune responses in a variety of autoimmune diseases.
	7. 439 Accesses	Review Stem cell therapy for retinal diseases: update Rubens Siqueira Stem Cell Research & Therapy 2011, 2:50 (29 December 2011) Abstract \| Full text \| PDF \| PubMed
	8. 357 Accesses	Research Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia Jung Lim, Chang Jeong, Jin Jun, Seong Kim, Chung Ryu, Yun Hou, Wonil Oh, Jong Chang, Sin-Soo Jeun Stem Cell Research & Therapy 2011, 2:38 (22 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells administered intrathecally by lumbar puncture significantly reduced ischemic damage in a stroke-affected rat model, demonstrating the potential of this delivery method in the treatment of brain injuries or neurodegenerative disorders.
	9. 348 Accesses	Review Bone tissue engineering with human stem cells Darja Marolt, Miomir Knezevic, Gordana Vunjak-Novakovic Stem Cell Research & Therapy 2010, 1:10 (4 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Using human stem cells for bone tissue engineering may be a viable alternative to treating bone defects with autologous bone grafting or implanting bone substitute materials.
	10. 348 Accesses	Research A novel serum-free medium for the expansion of human mesenchymal stem cells Lucas G Chase, Uma Lakshmipathy, Luis A Solchaga, Mahendra S Rao, Mohan C Vemuri Stem Cell Research & Therapy 2010, 1:8 (2 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A novel serum-free mesenchymal stem cell culture medium could substitute ill-defined traditional culture medium for research applications – an important step in the development of a more clinically relevant culture system.
	11. 331 Accesses	Review The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms Sara Morando, Tiziana Vigo, Marianna Esposito, Simona Casazza, Giovanni Novi, Maria Principato, Roberto Furlan, Antonio Uccelli Stem Cell Research & Therapy 2012, 3:3 (26 January 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Many studies have demonstrated that mesenchymal stem cells are effective in the treatment of experimental autoimmune encephalomyelitis (EAE) and may have potential as a therapeutic option in multiple sclerosis.
	12. 278 Accesses	Review Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells Jeffrey M Gimble, Farshid Guilak, Bruce A Bunnell Stem Cell Research & Therapy 2010, 1:19 (29 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gimble et al. review the clinical evidence using autologous adipose-derived cells that have been published in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines.
	13. 251 Accesses	Review Topical delivery of mesenchymal stem cells and their function in wounds J Michael Sorrell, Arnold I Caplan Stem Cell Research & Therapy 2010, 1:30 (24 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sorrell and Caplan review methods being developed to deliver mesenchymal stem cells to skin and other wounds in a timely fashion, and in sufficient numbers to have a therapeutic benefit.
	14. 245 Accesses	Review Mesenchymal stem cell effects on T-cell effector pathways Michelle M Duffy, Thomas Ritter, Rhodri Ceredig, Matthew D Griffin Stem Cell Research & Therapy 2011, 2:34 (11 August 2011) Abstract \| Full text \| PDF \| PubMed
	15. 235 Accesses	Research Efficient, high-throughput transfection of human embryonic stem cells Jennifer C Moore, Kristin Atze, Percy L Yeung, Alana J Toro-Ramos, Cynthia Camarillo, Kevin Thompson, Christopher L Ricupero, Mark A Brenneman, Rick I Cohen, Ronald P Hart Stem Cell Research & Therapy 2010, 1:23 (26 July 2010) Abstract \| Full text \| PDF \| PubMed
	16. 236 Accesses	Research Fibroblasts derived from human embryonic stem cells direct development and repair of 3D human skin equivalents Yulia Shamis, Kyle J Hewitt, Mark W Carlson, Mariam Margvelashvilli, Shumin Dong, Catherine K Kuo, Laurence Daheron, Christophe Egles, Jonathan A Garlick Stem Cell Research & Therapy 2011, 2:10 (21 February 2011) Abstract \| Full text \| PDF \| PubMed
	17. 236 Accesses	Review DNA methylation in stem cell renewal and multipotency María Berdasco, Manel Esteller Stem Cell Research & Therapy 2011, 2:42 (31 October 2011) Abstract \| Full text \| PDF \| PubMed
	18. 224 Accesses	Commentary Eyes open to stem cells: safety trial may pave the way for cell therapy to treat retinal disease in patients Reinhold J Medina, Desmond B Archer, Alan W Stitt Stem Cell Research & Therapy 2011, 2:47 (7 December 2011) Abstract \| Full text \| PDF \| PubMed
	19. 219 Accesses	Research Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6 Svitlana Danchuk, Joni H Ylostalo, Fokhrul Hossain, Randy Sorge, Austin Ramsey, Ryan W Bonvillain, Joseph A Lasky, Bruce A Bunnell, David A Welsh, Darwin J Prockop, Deborah E Sullivan Stem Cell Research & Therapy 2011, 2:27 (13 May 2011) Abstract \| Full text \| PDF \| PubMed \| F1000 Medicine \| Editor’s summary Therapy with human multipotent stromal cells isolated from bone marrow was able to significantly reduce acute lung injury in mice within 48 hours, paving the way for clinical trials.
	20. 216 Accesses	Review Induced pluripotent stem cells in the study of neurological diseases Mario A Saporta, Marica Grskovic, John T Dimos Stem Cell Research & Therapy 2011, 2:37 (21 September 2011) Abstract \| Full text \| PDF \| PubMed
	21. 214 Accesses	Research Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin Michael P Demars, Amelia Bartholomew, Zuzana Strakova, Orly Lazarov Stem Cell Research & Therapy 2011, 2:36 (30 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Soluble amyloid precursor protein alpha (sAPPα) regulates the proliferation of adult neural progenitor cells, mesenchymal stem cells and human placenta-derived stem cells by signalling through mitogen-activated protein kinase pathways.
	22. 213 Accesses	Research Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia Lisa McGinley, Jill McMahon, Padraig Strappe, Frank Barry, Mary Murphy, Daniel O'Toole, Timothy O'Brien Stem Cell Research & Therapy 2011, 2:12 (7 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells (MSCs) can be efficiently transduced in vitro to express a variety of therapeutic genes using a lentiviral vector, with potential to improve the efficacy of MSC-based therapies.
	23. 209 Accesses	Research Immunomodulatory properties of stem cells from human exfoliated deciduous teeth Takayoshi Yamaza, Akiyama Kentaro, Chider Chen, Yi Liu, Yufang Shi, Stan Gronthos, Songlin Wang, Songtao Shi Stem Cell Research & Therapy 2010, 1:5 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary SHED (stem cells from human exfoliated deciduous teeth) transplantation was used to treat systemic lupus erythematosus (SLE) in a mouse model, suggesting SHED are a feasible stem cell source for treating immune disorders.
	24. 203 Accesses	Research Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model Ashlee E Watts, Amy E Yeager, Oleg V Kopyov, Alan J Nixon Stem Cell Research & Therapy 2011, 2:4 (27 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Intralesional injection with fetal derived embryonic-like stem cells resulted in structural improvements to healing tendon in a large animal tendonitis model, suggesting pluripotent stem cells can effect regeneration rather than repair.
	25. 202 Accesses	Research Constitutive G_sactivation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice Edward C Hsiao, Trieu D Nguyen, Jennifer K Ng, Mark J Scott, Wei Chun Chang, Hengameh Zahed, Bruce R Conklin Stem Cell Research & Therapy 2011, 2:11 (4 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A modular system allows the rapid generation of tetracycline-regulated expression constructs for gene expression studies in embryonic stem cells and mice, and the rapid introduction of different combinations of promoters and expressed transgenes.