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	1. 14628 Accesses	Review Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications Soufiane Ghannam, Carine Bouffi, Farida Djouad, Christian Jorgensen, Danièle Noël Stem Cell Research & Therapy 2010, 1:2 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ghannam et al discuss the targets and mechanisms of mesenchymal stem cell (MSC)-mediated immunosuppression, and the potential use of MSCs to modulate immune responses in a variety of autoimmune diseases.
	2. 11262 Accesses	Research A novel serum-free medium for the expansion of human mesenchymal stem cells Lucas G Chase, Uma Lakshmipathy, Luis A Solchaga, Mahendra S Rao, Mohan C Vemuri Stem Cell Research & Therapy 2010, 1:8 (2 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A novel serum-free mesenchymal stem cell culture medium could substitute ill-defined traditional culture medium for research applications – an important step in the development of a more clinically relevant culture system.
	3. 9085 Accesses	Review Bone tissue engineering with human stem cells Darja Marolt, Miomir Knezevic, Gordana Vunjak-Novakovic Stem Cell Research & Therapy 2010, 1:10 (4 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Using human stem cells for bone tissue engineering may be a viable alternative to treating bone defects with autologous bone grafting or implanting bone substitute materials.
	4. 7287 Accesses	Research Immunomodulatory properties of stem cells from human exfoliated deciduous teeth Takayoshi Yamaza, Akiyama Kentaro, Chider Chen, Yi Liu, Yufang Shi, Stan Gronthos, Songlin Wang, Songtao Shi Stem Cell Research & Therapy 2010, 1:5 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary SHED (stem cells from human exfoliated deciduous teeth) transplantation was used to treat systemic lupus erythematosus (SLE) in a mouse model, suggesting SHED are a feasible stem cell source for treating immune disorders.
	5. 6710 Accesses	Review Experimental approaches for the generation of induced pluripotent stem cells Cesar A Sommer, Gustavo Mostoslavsky Stem Cell Research & Therapy 2010, 1:26 (10 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sommer and Mostoslavsky summarize current reprogramming methodologies, focusing on the production of genetically unmanipulated induced pluripotent stem (iPS) cells, highlighting important technical details that could influence the biological properties of these cells.
	6. 6463 Accesses	Review Epigenetics of induced pluripotency, the seven-headed dragon Ugljesa Djuric, James Ellis Stem Cell Research & Therapy 2010, 1:3 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Djuric and Ellis highlight advancements in the understanding of dynamic epigenetic changes occurring in the cell reprogramming process, and how aberrant epigenetic remodeling may impact on applications of iPS cell technology.
	7. 6317 Accesses	Review Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells Jeffrey M Gimble, Farshid Guilak, Bruce A Bunnell Stem Cell Research & Therapy 2010, 1:19 (29 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gimble et al. review the clinical evidence using autologous adipose-derived cells that have been published in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines.
	8. 5900 Accesses	Commentary Challenges in the clinical application of induced pluripotent stem cells Douglas Sipp Stem Cell Research & Therapy 2010, 1:9 (12 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Douglas Sipp outlines the challenges faced in the clinical application of human induced pluripotent (iPS) stem cells, and argues that confronting the problems will facilitate revolutionary advances in cell therapy.
	9. 5322 Accesses	Review Stem cells for the treatment of neurodegenerative diseases Elise Dantuma, Stephanie Merchant, Kiminobu Sugaya Stem Cell Research & Therapy 2010, 1:37 (10 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The advancement of clinical application of stem cells for treating neurodegenerative diseases is building, but care needs to be taken moving forwards with extensive scrutiny of trial protocols.
	10. 5279 Accesses	Research Efficient, high-throughput transfection of human embryonic stem cells Jennifer C Moore, Kristin Atze, Percy L Yeung, Alana J Toro-Ramos, Cynthia Camarillo, Kevin Thompson, Christopher L Ricupero, Mark A Brenneman, Rick I Cohen, Ronald P Hart Stem Cell Research & Therapy 2010, 1:23 (26 July 2010) Abstract \| Full text \| PDF \| PubMed
	11. 5102 Accesses	Editorial Welcome to Stem Cell Research & Therapy Ann Donnelly, Surayya Johar, Timothy O'Brien, Rocky S Tuan Stem Cell Research & Therapy 2010, 1:1 (15 March 2010) Full text \| PDF \| PubMed \| Editor’s summary Timothy O’Brien and Rocky Tuan, Editors-in-Chief, introduce Stem Cell Research & Therapy, the major forum for translational research into stem cell therapies.
	12. 4983 Accesses	Research Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model Ashlee E Watts, Amy E Yeager, Oleg V Kopyov, Alan J Nixon Stem Cell Research & Therapy 2011, 2:4 (27 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Intralesional injection with fetal derived embryonic-like stem cells resulted in structural improvements to healing tendon in a large animal tendonitis model, suggesting pluripotent stem cells can effect regeneration rather than repair.
	13. 4935 Accesses	Review Advances in mesenchymal stem cell-mediated gene therapy for cancer Roisin M Dwyer, Sonja Khan, Frank P Barry, Timothy O'Brien, Michael J Kerin Stem Cell Research & Therapy 2010, 1:25 (9 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Exploiting the tumour-homing capacity of mesenchymal stem cells (MSCs) for gene delivery has potential for MSC-mediated delivery of therapeutic agents directly to tumour tissue.
	14. 4413 Accesses	Research Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia Jung Lim, Chang Jeong, Jin Jun, Seong Kim, Chung Ryu, Yun Hou, Wonil Oh, Jong Chang, Sin-Soo Jeun Stem Cell Research & Therapy 2011, 2:38 (22 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells administered intrathecally by lumbar puncture significantly reduced ischemic damage in a stroke-affected rat model, demonstrating the potential of this delivery method in the treatment of brain injuries or neurodegenerative disorders.
	15. 4166 Accesses	Research Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6 Svitlana Danchuk, Joni H Ylostalo, Fokhrul Hossain, Randy Sorge, Austin Ramsey, Ryan W Bonvillain, Joseph A Lasky, Bruce A Bunnell, David A Welsh, Darwin J Prockop, Deborah E Sullivan Stem Cell Research & Therapy 2011, 2:27 (13 May 2011) Abstract \| Full text \| PDF \| PubMed \| F1000 Medicine \| Editor’s summary Therapy with human multipotent stromal cells isolated from bone marrow was able to significantly reduce acute lung injury in mice within 48 hours, paving the way for clinical trials.
	16. 4149 Accesses	Research Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia Lisa McGinley, Jill McMahon, Padraig Strappe, Frank Barry, Mary Murphy, Daniel O'Toole, Timothy O'Brien Stem Cell Research & Therapy 2011, 2:12 (7 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells (MSCs) can be efficiently transduced in vitro to express a variety of therapeutic genes using a lentiviral vector, with potential to improve the efficacy of MSC-based therapies.
	17. 4048 Accesses	Review Cancerous stem cells: deviant stem cells with cancer-causing misbehavior Julie M Chandler, Eric Lagasse Stem Cell Research & Therapy 2010, 1:13 (20 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cancerous stem cells, the result of changes in signaling pathways involved in stem cell survival and proliferation, show resistance to cancer therapies, and understanding their unique characteristics is key to targeting therapies towards them.
	18. 3982 Accesses	Review Topical delivery of mesenchymal stem cells and their function in wounds J Michael Sorrell, Arnold I Caplan Stem Cell Research & Therapy 2010, 1:30 (24 September 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sorrell and Caplan review methods being developed to deliver mesenchymal stem cells to skin and other wounds in a timely fashion, and in sufficient numbers to have a therapeutic benefit.
	19. 3976 Accesses	Research Activin A expression regulates multipotency of mesenchymal progenitor cells Farida Djouad, Wesley M Jackson, Brent E Bobick, Sasa Janjanin, Yingjie Song, George TJ Huang, Rocky S Tuan Stem Cell Research & Therapy 2010, 1:11 (4 May 2010) Abstract \| Full text \| PDF \| PubMed \| F1000 Medicine \| Editor’s summary Activin A expression acts as a functional marker for multipotent mesenchymal progenitor cells, allowing for identification of the more desirable cell types for use in regenerative medicine.
	20. 3909 Accesses	Research Fibroblasts derived from human embryonic stem cells direct development and repair of 3D human skin equivalents Yulia Shamis, Kyle J Hewitt, Mark W Carlson, Mariam Margvelashvilli, Shumin Dong, Catherine K Kuo, Laurence Daheron, Christophe Egles, Jonathan A Garlick Stem Cell Research & Therapy 2011, 2:10 (21 February 2011) Abstract \| Full text \| PDF \| PubMed
	21. 3885 Accesses	Review Mesenchymal stem cells for the treatment of systemic lupus erythematosus: is the cure for connective tissue diseases within connective tissue? Flavio A Carrion, Fernando E Figueroa Stem Cell Research & Therapy 2011, 2:23 (11 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells have been successfully applied in patients with severe treatment-refractory systemic lupus erythematosus in uncontrolled phase I and II trials suggesting larger randomized controlled trials should be performed.
	22. 3691 Accesses	Research Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype Casey L Korecki, Juan M Taboas, Rocky S Tuan, James C Iatridis Stem Cell Research & Therapy 2010, 1:18 (16 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation towards nucleus pulposus-like phenotype with characteristics of the developing intervertebral disc (IVD), suggesting notochordal cells as a promising target for IVD repair.
	23. 3665 Accesses	Review Molecular mechanisms of pluripotency and reprogramming Jie Na, Jordan Plews, Jianliang Li, Patompon Wongtrakoongate, Timo Tuuri, Anis Feki, Peter W Andrews, Christian Unger Stem Cell Research & Therapy 2010, 1:33 (25 October 2010) Abstract \| Full text \| PDF \| PubMed
	24. 3658 Accesses	Review Extrinsic regulation of satellite cell specification C Florian Bentzinger, Julia von Maltzahn, Michael A Rudnicki Stem Cell Research & Therapy 2010, 1:27 (26 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The existence of numerous physiological factors that are involved in the regulation of satellite cells provides an opportunity for the development of drugs that mimic or interfere with these molecules
	25. 3634 Accesses	Research Selection and reliability of internal reference genes for quantitative PCR verification of transcriptomics during the differentiation process of porcine adult mesenchymal stem cells Elisa Monaco, Massimo Bionaz, Alecsandra de Lima, Walter L Hurley, Juan J Loor, Matthew B Wheeler Stem Cell Research & Therapy 2010, 1:7 (30 March 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new protocol, combining microarray data with pair-wise gene analysis, identified novel reliable housekeeping genes for data normalization of adult porcine stem cells, and can be used in other similar experiments.