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	1. 22985 Accesses	Review Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications Soufiane Ghannam, Carine Bouffi, Farida Djouad, Christian Jorgensen, Danièle Noël Stem Cell Research & Therapy 2010, 1:2 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ghannam et al discuss the targets and mechanisms of mesenchymal stem cell (MSC)-mediated immunosuppression, and the potential use of MSCs to modulate immune responses in a variety of autoimmune diseases.
	2. 20927 Accesses	Research SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells Jagadeesh K Venkatesan, Myriam Ekici, Henning Madry, Gertrud Schmitt, Dieter Kohn, Magali Cucchiarini Stem Cell Research & Therapy 2012, 3:22 (28 June 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Transfer of SOX9 via replication-defective recombinant adeno-associated virus (rAAV) vector enhances the chondrogenic potential of human mesenchymal stem cells, with potential for future therapeutic applications to restore articular cartilage defects.
	3. 15820 Accesses	Research A novel serum-free medium for the expansion of human mesenchymal stem cells Lucas G Chase, Uma Lakshmipathy, Luis A Solchaga, Mahendra S Rao, Mohan C Vemuri Stem Cell Research & Therapy 2010, 1:8 (2 April 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel serum-free mesenchymal stem cell culture medium could substitute ill-defined traditional culture medium for research applications – an important step in the development of a more clinically relevant culture system.
	4. 14369 Accesses	Review Bone tissue engineering with human stem cells Darja Marolt, Miomir Knezevic, Gordana Vunjak-Novakovic Stem Cell Research & Therapy 2010, 1:10 (4 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Using human stem cells for bone tissue engineering may be a viable alternative to treating bone defects with autologous bone grafting or implanting bone substitute materials.
	5. 10374 Accesses	Research Immunomodulatory properties of stem cells from human exfoliated deciduous teeth Takayoshi Yamaza, Akiyama Kentaro, Chider Chen, Yi Liu, Yufang Shi, Stan Gronthos, Songlin Wang, Songtao Shi Stem Cell Research & Therapy 2010, 1:5 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary SHED (stem cells from human exfoliated deciduous teeth) transplantation was used to treat systemic lupus erythematosus (SLE) in a mouse model, suggesting SHED are a feasible stem cell source for treating immune disorders.
	6. 9651 Accesses	Research Efficient, high-throughput transfection of human embryonic stem cells Jennifer C Moore, Kristin Atze, Percy L Yeung, Alana J Toro-Ramos, Cynthia Camarillo, Kevin Thompson, Christopher L Ricupero, Mark A Brenneman, Rick I Cohen, Ronald P Hart Stem Cell Research & Therapy 2010, 1:23 (26 July 2010) Abstract \| Full text \| PDF \| PubMed
	7. 9530 Accesses	Review Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells Jeffrey M Gimble, Farshid Guilak, Bruce A Bunnell Stem Cell Research & Therapy 2010, 1:19 (29 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gimble et al. review the clinical evidence using autologous adipose-derived cells that have been published in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines.
	8. 9268 Accesses	Research Phenotypical and functional characteristics of mesenchymal stem cells from bone marrow: comparison of culture using different media supplemented with human platelet lysate or fetal bovine serum Nesrine Azouna, Faouzi Jenhani, Zohra Regaya, Lamia Berraeis, Tarek Othman, Elfi Ducrocq, Jorge Domenech Stem Cell Research & Therapy 2012, 3:6 (14 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mesenchymal stem cells expanded in human platelet lysate supplemented media without fetal bovine serum (FBS) retain their phenotype and differentiation capacity, while an increased growth rate may allow for reduced culture time.
	9. 8572 Accesses	Review Experimental approaches for the generation of induced pluripotent stem cells Cesar A Sommer, Gustavo Mostoslavsky Stem Cell Research & Therapy 2010, 1:26 (10 August 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Sommer and Mostoslavsky summarize current reprogramming methodologies, focusing on the production of genetically unmanipulated induced pluripotent stem (iPS) cells, highlighting important technical details that could influence the biological properties of these cells.
	10. 8361 Accesses	Research Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model Ashlee E Watts, Amy E Yeager, Oleg V Kopyov, Alan J Nixon Stem Cell Research & Therapy 2011, 2:4 (27 January 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Intralesional injection with fetal derived embryonic-like stem cells resulted in structural improvements to healing tendon in a large animal tendonitis model, suggesting pluripotent stem cells can effect regeneration rather than repair.
	11. 8326 Accesses	Review Stem cells for the treatment of neurodegenerative diseases Elise Dantuma, Stephanie Merchant, Kiminobu Sugaya Stem Cell Research & Therapy 2010, 1:37 (10 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The advancement of clinical application of stem cells for treating neurodegenerative diseases is building, but care needs to be taken moving forwards with extensive scrutiny of trial protocols.
	12. 8317 Accesses	Review Epigenetics of induced pluripotency, the seven-headed dragon Ugljesa Djuric, James Ellis Stem Cell Research & Therapy 2010, 1:3 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Djuric and Ellis highlight advancements in the understanding of dynamic epigenetic changes occurring in the cell reprogramming process, and how aberrant epigenetic remodeling may impact on applications of iPS cell technology.
	13. 8071 Accesses	Research Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia Jung Lim, Chang Jeong, Jin Jun, Seong Kim, Chung Ryu, Yun Hou, Wonil Oh, Jong Chang, Sin-Soo Jeun Stem Cell Research & Therapy 2011, 2:38 (22 September 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mesenchymal stem cells administered intrathecally by lumbar puncture significantly reduced ischemic damage in a stroke-affected rat model, demonstrating the potential of this delivery method in the treatment of brain injuries or neurodegenerative disorders.
	14. 8062 Accesses	Review Growth factor regulation of proliferation and survival of multipotential stromal cells Melanie Rodrigues, Linda G Griffith, Alan Wells Stem Cell Research & Therapy 2010, 1:32 (26 October 2010) Abstract \| Full text \| PDF \| PubMed
	15. 7951 Accesses	Research Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia Lisa McGinley, Jill McMahon, Padraig Strappe, Frank Barry, Mary Murphy, Daniel O'Toole, Timothy O'Brien Stem Cell Research & Therapy 2011, 2:12 (7 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells (MSCs) can be efficiently transduced in vitro to express a variety of therapeutic genes using a lentiviral vector, with potential to improve the efficacy of MSC-based therapies.
	16. 7516 Accesses	Research Fibroblasts derived from human embryonic stem cells direct development and repair of 3D human skin equivalents Yulia Shamis, Kyle J Hewitt, Mark W Carlson, Mariam Margvelashvilli, Shumin Dong, Catherine K Kuo, Laurence Daheron, Christophe Egles, Jonathan A Garlick Stem Cell Research & Therapy 2011, 2:10 (21 February 2011) Abstract \| Full text \| PDF \| PubMed
	17. 7491 Accesses	Commentary Challenges in the clinical application of induced pluripotent stem cells Douglas Sipp Stem Cell Research & Therapy 2010, 1:9 (12 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Douglas Sipp outlines the challenges faced in the clinical application of human induced pluripotent (iPS) stem cells, and argues that confronting the problems will facilitate revolutionary advances in cell therapy.
	18. 7433 Accesses	Review Advances in mesenchymal stem cell-mediated gene therapy for cancer Roisin M Dwyer, Sonja Khan, Frank P Barry, Timothy O'Brien, Michael J Kerin Stem Cell Research & Therapy 2010, 1:25 (9 August 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Exploiting the tumour-homing capacity of mesenchymal stem cells (MSCs) for gene delivery has potential for MSC-mediated delivery of therapeutic agents directly to tumour tissue.
	19. 7401 Accesses	Research Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation toward a young nucleus pulposus phenotype Casey L Korecki, Juan M Taboas, Rocky S Tuan, James C Iatridis Stem Cell Research & Therapy 2010, 1:18 (16 June 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Notochordal cell conditioned medium stimulates mesenchymal stem cell differentiation towards nucleus pulposus-like phenotype with characteristics of the developing intervertebral disc (IVD), suggesting notochordal cells as a promising target for IVD repair.
	20. 7179 Accesses	Research Effects of intravenous administration of allogenic bone marrow- and adipose tissue-derived mesenchymal stem cells on functional recovery and brain repair markers in experimental ischemic stroke María Gutiérrez-Fernández, Berta Rodríguez-Frutos, Jaime Ramos-Cejudo, M Teresa Vallejo-Cremades, Blanca Fuentes, Sebastián Cerdán, Exuperio Díez-Tejedor Stem Cell Research & Therapy 2013, 4:11 (28 January 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Rats treated intravenously with bone marrow- or adipose-derived mesenchymal stem cells after experimental ischemic stroke showed improvements in brain and nerve repair, and ability to complete behavioural tasks.
	21. 6964 Accesses	Research Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6 Svitlana Danchuk, Joni H Ylostalo, Fokhrul Hossain, Randy Sorge, Austin Ramsey, Ryan W Bonvillain, Joseph A Lasky, Bruce A Bunnell, David A Welsh, Darwin J Prockop, Deborah E Sullivan Stem Cell Research & Therapy 2011, 2:27 (13 May 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 \| Editor’s summary Therapy with human multipotent stromal cells isolated from bone marrow was able to significantly reduce acute lung injury in mice within 48 hours, paving the way for clinical trials.
	22. 6741 Accesses	Research Characterization of bone marrow derived mesenchymal stem cells in suspension Kentaro Akiyama, Yong-Ouk You, Takayoshi Yamaza, Chider Chen, Liang Tang, Yan Jin, Xiao-Dong Chen, Stan Gronthos, Songtao Shi Stem Cell Research & Therapy 2012, 3:40 (19 October 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Identification of a new subset of bone marrow mesenchymal stem cells (BMMSCs) with superior immunomodulatory properties that may be lost in the standard isolation assay could aid improvements in immunotherapy.
	23. 6703 Accesses	Research Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells Seiga Ohmine, Allan B Dietz, Michael C Deeds, Katherine A Hartjes, David R Miller, Tayaramma Thatava, Toshie Sakuma, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:46 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Hematopoietic progenitor cells and peripheral blood mononuclear cells could be ideal somatic cell sources for clinical-grade induced pluripotent stem cell (iPSC) derivation, allowing minimally invasive tissue procurement and rapid cellular reprogramming.
	24. 6664 Accesses	Editorial Stem cells and regenerative medicine Mahendra Rao Stem Cell Research & Therapy 2012, 3:27 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mahendra Rao introduces a new series on clinical applications of stem cells, discussing the progress made in taking stem cells from the bench to the bedside and the challenges remaining.
	25. 6522 Accesses	Review Mesenchymal stem cell effects on T-cell effector pathways Michelle M Duffy, Thomas Ritter, Rhodri Ceredig, Matthew D Griffin Stem Cell Research & Therapy 2011, 2:34 (11 August 2011) Abstract \| Full text \| PDF \| PubMed