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	1. 5305 Accesses	Review Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications Soufiane Ghannam, Carine Bouffi, Farida Djouad, Christian Jorgensen, Danièle Noël Stem Cell Research & Therapy 2010, 1:2 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ghannam et al discuss the targets and mechanisms of mesenchymal stem cell (MSC)-mediated immunosuppression, and the potential use of MSCs to modulate immune responses in a variety of autoimmune diseases.
	2. 4767 Accesses	Research Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model Ashlee E Watts, Amy E Yeager, Oleg V Kopyov, Alan J Nixon Stem Cell Research & Therapy 2011, 2:4 (27 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Intralesional injection with fetal derived embryonic-like stem cells resulted in structural improvements to healing tendon in a large animal tendonitis model, suggesting pluripotent stem cells can effect regeneration rather than repair.
	3. 4413 Accesses	Research Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia Jung Lim, Chang Jeong, Jin Jun, Seong Kim, Chung Ryu, Yun Hou, Wonil Oh, Jong Chang, Sin-Soo Jeun Stem Cell Research & Therapy 2011, 2:38 (22 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells administered intrathecally by lumbar puncture significantly reduced ischemic damage in a stroke-affected rat model, demonstrating the potential of this delivery method in the treatment of brain injuries or neurodegenerative disorders.
	4. 4348 Accesses	Research A novel serum-free medium for the expansion of human mesenchymal stem cells Lucas G Chase, Uma Lakshmipathy, Luis A Solchaga, Mahendra S Rao, Mohan C Vemuri Stem Cell Research & Therapy 2010, 1:8 (2 April 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A novel serum-free mesenchymal stem cell culture medium could substitute ill-defined traditional culture medium for research applications – an important step in the development of a more clinically relevant culture system.
	5. 4166 Accesses	Research Human multipotent stromal cells attenuate lipopolysaccharide-induced acute lung injury in mice via secretion of tumor necrosis factor-α-induced protein 6 Svitlana Danchuk, Joni H Ylostalo, Fokhrul Hossain, Randy Sorge, Austin Ramsey, Ryan W Bonvillain, Joseph A Lasky, Bruce A Bunnell, David A Welsh, Darwin J Prockop, Deborah E Sullivan Stem Cell Research & Therapy 2011, 2:27 (13 May 2011) Abstract \| Full text \| PDF \| PubMed \| F1000 Medicine \| Editor’s summary Therapy with human multipotent stromal cells isolated from bone marrow was able to significantly reduce acute lung injury in mice within 48 hours, paving the way for clinical trials.
	6. 4149 Accesses	Research Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia Lisa McGinley, Jill McMahon, Padraig Strappe, Frank Barry, Mary Murphy, Daniel O'Toole, Timothy O'Brien Stem Cell Research & Therapy 2011, 2:12 (7 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells (MSCs) can be efficiently transduced in vitro to express a variety of therapeutic genes using a lentiviral vector, with potential to improve the efficacy of MSC-based therapies.
	7. 3909 Accesses	Research Fibroblasts derived from human embryonic stem cells direct development and repair of 3D human skin equivalents Yulia Shamis, Kyle J Hewitt, Mark W Carlson, Mariam Margvelashvilli, Shumin Dong, Catherine K Kuo, Laurence Daheron, Christophe Egles, Jonathan A Garlick Stem Cell Research & Therapy 2011, 2:10 (21 February 2011) Abstract \| Full text \| PDF \| PubMed
	8. 3885 Accesses	Review Mesenchymal stem cells for the treatment of systemic lupus erythematosus: is the cure for connective tissue diseases within connective tissue? Flavio A Carrion, Fernando E Figueroa Stem Cell Research & Therapy 2011, 2:23 (11 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mesenchymal stem cells have been successfully applied in patients with severe treatment-refractory systemic lupus erythematosus in uncontrolled phase I and II trials suggesting larger randomized controlled trials should be performed.
	9. 3504 Accesses	Review Stem cells for the treatment of neurodegenerative diseases Elise Dantuma, Stephanie Merchant, Kiminobu Sugaya Stem Cell Research & Therapy 2010, 1:37 (10 December 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The advancement of clinical application of stem cells for treating neurodegenerative diseases is building, but care needs to be taken moving forwards with extensive scrutiny of trial protocols.
	10. 3248 Accesses	Research Constitutive G_sactivation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice Edward C Hsiao, Trieu D Nguyen, Jennifer K Ng, Mark J Scott, Wei Chun Chang, Hengameh Zahed, Bruce R Conklin Stem Cell Research & Therapy 2011, 2:11 (4 March 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A modular system allows the rapid generation of tetracycline-regulated expression constructs for gene expression studies in embryonic stem cells and mice, and the rapid introduction of different combinations of promoters and expressed transgenes.
	11. 3238 Accesses	Review Bone tissue engineering with human stem cells Darja Marolt, Miomir Knezevic, Gordana Vunjak-Novakovic Stem Cell Research & Therapy 2010, 1:10 (4 May 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Using human stem cells for bone tissue engineering may be a viable alternative to treating bone defects with autologous bone grafting or implanting bone substitute materials.
	12. 3099 Accesses	Research Immunomodulatory properties of stem cells from human exfoliated deciduous teeth Takayoshi Yamaza, Akiyama Kentaro, Chider Chen, Yi Liu, Yufang Shi, Stan Gronthos, Songlin Wang, Songtao Shi Stem Cell Research & Therapy 2010, 1:5 (15 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary SHED (stem cells from human exfoliated deciduous teeth) transplantation was used to treat systemic lupus erythematosus (SLE) in a mouse model, suggesting SHED are a feasible stem cell source for treating immune disorders.
	13. 3039 Accesses	Review Engineering a stem cell house into a home Penny M Gilbert, Helen M Blau Stem Cell Research & Therapy 2011, 2:3 (31 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gilbert and Blau review how combining stem cell biology and creative bioengineering technology could expand our understanding of regulation of the stem cell niche.
	14. 2928 Accesses	Review Mesenchymal stem cell effects on T-cell effector pathways Michelle M Duffy, Thomas Ritter, Rhodri Ceredig, Matthew D Griffin Stem Cell Research & Therapy 2011, 2:34 (11 August 2011) Abstract \| Full text \| PDF \| PubMed
	15. 2730 Accesses	Research Characterization of the radioresponse of human apical papilla-derived cells Shigehiro Abe, Keiichi Hamada, Satoshi Yamaguchi, Teruo Amagasa, Masahiko Miura Stem Cell Research & Therapy 2011, 2:2 (20 January 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Stem cells derived from apical papilla-derived cells (APDCs) are more radioresistant than bulk APDCs, exhibiting a reduction in ability to form hard tissue following irradiation not seen with bulk APDCs.
	16. 2611 Accesses	Research Efficient, high-throughput transfection of human embryonic stem cells Jennifer C Moore, Kristin Atze, Percy L Yeung, Alana J Toro-Ramos, Cynthia Camarillo, Kevin Thompson, Christopher L Ricupero, Mark A Brenneman, Rick I Cohen, Ronald P Hart Stem Cell Research & Therapy 2010, 1:23 (26 July 2010) Abstract \| Full text \| PDF \| PubMed
	17. 2404 Accesses	Review Induced pluripotent stem cells in the study of neurological diseases Mario A Saporta, Marica Grskovic, John T Dimos Stem Cell Research & Therapy 2011, 2:37 (21 September 2011) Abstract \| Full text \| PDF \| PubMed
	18. 2310 Accesses	Review Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells Jeffrey M Gimble, Farshid Guilak, Bruce A Bunnell Stem Cell Research & Therapy 2010, 1:19 (29 June 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gimble et al. review the clinical evidence using autologous adipose-derived cells that have been published in the fields of gastroenterology, neurology, orthopedics, reconstructive surgery, and related clinical disciplines.
	19. 2293 Accesses	Research Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells Seiga Ohmine, Allan B Dietz, Michael C Deeds, Katherine A Hartjes, David R Miller, Tayaramma Thatava, Toshie Sakuma, Yogish C Kudva, Yasuhiro Ikeda Stem Cell Research & Therapy 2011, 2:46 (16 November 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Hematopoietic progenitor cells and peripheral blood mononuclear cells could be ideal somatic cell sources for clinical-grade induced pluripotent stem cell (iPSC) derivation, allowing minimally invasive tissue procurement and rapid cellular reprogramming.
	20. 2184 Accesses	Review Mesenchymal stem cell-based therapies in regenerative medicine: applications in rheumatology Marie Maumus, David Guérit, Karine Toupet, Christian Jorgensen, Danièle Noël Stem Cell Research & Therapy 2011, 2:14 (18 March 2011) Abstract \| Full text \| PDF \| PubMed
	21. 2174 Accesses	Review The role of induced pluripotent stem cells in regenerative medicine: neurodegenerative diseases Jun Peng, Xianmin Zeng Stem Cell Research & Therapy 2011, 2:32 (28 July 2011) Abstract \| Full text \| PDF \| PubMed
	22. 2107 Accesses	Review Amnion-derived stem cells: in quest of clinical applications Toshio Miki Stem Cell Research & Therapy 2011, 2:25 (19 May 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Miki introduces a model theory to explain why so many amnion-derived cells possess stem cell characteristics, and reviews the therapeutic applications and pluripotency of amniotic epithelial cells.
	23. 2065 Accesses	Research Gene expression changes with differentiation of cord blood stem cells to respiratory epithelial cells: a preliminary observation Michael J Berger, Sharon R Minnerath, Sheryl D Adams, Barbara M Tigges, Stacey L Sprague, David H McKenna Jr Stem Cell Research & Therapy 2011, 2:19 (13 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Berger et al. present an account of the changes in gene expression that accompany the differentiation of human umbilical cord blood (UCB)-derived stem cells toward type II pneumocytes.
	24. 2065 Accesses	Research Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells Caitlin E Filby, Robert Williamson, Peter van Kooy, Alice Pébay, Mirella Dottori, Ngaire J Elwood, Faten Zaibak Stem Cell Research & Therapy 2011, 2:16 (4 April 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Unlike human embryonic stem cells, stimulation of the Nodal signaling pathway with Activin A is insufficient to induce definitive endoderm formation from umbilical cord blood-derived unrestricted somatic stem cells (USSCs).
	25. 2048 Accesses	Review Experimental approaches for the generation of induced pluripotent stem cells Cesar A Sommer, Gustavo Mostoslavsky Stem Cell Research & Therapy 2010, 1:26 (10 August 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sommer and Mostoslavsky summarize current reprogramming methodologies, focusing on the production of genetically unmanipulated induced pluripotent stem (iPS) cells, highlighting important technical details that could influence the biological properties of these cells.