Stem Cell Research & Therapy | Article collections | Clinical applications of stem cells

Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation

Sebastiaan van Gorp, Marjolein Leerink, Osamu Kakinohana, Oleksandr Platoshyn, Camila Santucci, Jan Galik, Elbert A Joosten, Marian Hruska-Plochan, Danielle Goldberg, Silvia Marsala, Karl Johe, Joseph D Ciacci, Martin Marsala Stem Cell Research & Therapy 2013, 4:57 (28 May 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Human foetal stem cell grafts improve both motor and sensory functions in rats suffering from a spinal cord injury, demonstrating potential for cell replacement therapy in human spinal cord injuries.

Standardization of human stem cell pluripotency using bioinformatics

Michael W Nestor, Scott A Noggle Stem Cell Research & Therapy 2013, 4:37 (25 April 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Nestor and Noggle review approaches using bioinformatics and gene profiling to standardize pluripotency assays, one of the major hurdles in the development of high-throughput production of human stem cells for regenerative therapies.

Large animal models for stem cell therapy

John Harding, R Roberts, Oleg Mirochnitchenko Stem Cell Research & Therapy 2013, 4:23 (28 March 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Oleg Mirochnitchenko and colleagues discuss the importance and current status of large animal models in the preclinical validation of stem cell-based regenerative therapies, including their advantages and challenges.

Development of fully defined xeno-free culture system for the preparation and propagation of cell therapy-compliant human adipose stem cells

Mimmi Patrikoski, Miia Juntunen, Shayne Boucher, Andrew Campbell, Mohan C Vemuri, Bettina Mannerström, Susanna Miettinen Stem Cell Research & Therapy 2013, 4:27 (7 March 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Adipose stem cells cultured in novel xeno-free/serum-free conditions retained their stem cell characteristics, indicating that the culture conditions have potential future use in the development of clinical cell therapies.

Return of results in translational iPS cell research: considerations for donor informed consent

Geoffrey P Lomax, Kelly A Shepard Stem Cell Research & Therapy 2013, 4:6 (21 January 2013)

Abstract | Full text | PDF | PubMed | Editor’s summary

Lomax and Shepherd review the CIRM’s recommendations on informing tissue donors in disease-specific induced pluripotent stem (iPS) cell research, including gaining consent to recontact donors in the event of significant new findings.

US Food and Drug Administration international collaborations for cellular therapy product regulation

Judith A Arcidiacono, Joan W Blair, Kimberly A Benton Stem Cell Research & Therapy 2012, 3:38 (28 September 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Judith Arcidiacono and colleagues from the US Food and Drug Administration (FDA) review efforts towards international regulatory convergence for cellular therapy products.

Glia: an emerging target for neurological disease therapy

Akshata A Almad, Nicholas J Maragakis Stem Cell Research & Therapy 2012, 3:37 (28 September 2012)

Almad and Maragakis discuss the role of glial cells in central nervous system diseases and the potential for glial cell replacement in neurological disease therapy.

Stem cells and regenerative medicine

Mahendra Rao Stem Cell Research & Therapy 2012, 3:27 (9 July 2012)

Mahendra Rao introduces a new series on clinical applications of stem cells, discussing the progress made in taking stem cells from the bench to the bedside and the challenges remaining.

The Aastrom experience

Ronnda L Bartel, Caryn Cramer, Kelly Ledford, Amy Longcore, Christopher Parrish, Theresa Stern, Sharon Watling, Frank Zeigler Stem Cell Research & Therapy 2012, 3:26 (9 July 2012)

Abstract | Full text | PDF | PubMed | Editor’s summary

Ronnda Bartel and colleagues describe their experience manufacturing an autologous differentiated cell product for the treatment of critical limb ischemia.

Mesenchymal stem cells for cartilage repair in osteoarthritis

Pawan K Gupta, Anjan K Das, Anoop Chullikana, Anish S Majumdar Stem Cell Research & Therapy 2012, 3:25 (9 July 2012)

The use of bone marrow stromal cells for cartilage repair and their therapeutic potential in osteoarthritis is discussed by Anish Majumdar and colleagues.

Stem cell therapy for the spinal cord

Eleanor M Donnelly, Jason Lamanna, Nicholas M Boulis Stem Cell Research & Therapy 2012, 3:24 (9 July 2012)

Nicholas Boulis and colleagues review clinical trials of stem cell transplantation into the spinal cord focusing on motor neuron diseases and spinal cord injury and discuss the optimization of delivery methods.

		Research Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation Sebastiaan van Gorp, Marjolein Leerink, Osamu Kakinohana, Oleksandr Platoshyn, Camila Santucci, Jan Galik, Elbert A Joosten, Marian Hruska-Plochan, Danielle Goldberg, Silvia Marsala, Karl Johe, Joseph D Ciacci, Martin Marsala Stem Cell Research & Therapy 2013, 4:57 (28 May 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Human foetal stem cell grafts improve both motor and sensory functions in rats suffering from a spinal cord injury, demonstrating potential for cell replacement therapy in human spinal cord injuries.
		Review Standardization of human stem cell pluripotency using bioinformatics Michael W Nestor, Scott A Noggle Stem Cell Research & Therapy 2013, 4:37 (25 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Nestor and Noggle review approaches using bioinformatics and gene profiling to standardize pluripotency assays, one of the major hurdles in the development of high-throughput production of human stem cells for regenerative therapies.
		Review Large animal models for stem cell therapy John Harding, R Roberts, Oleg Mirochnitchenko Stem Cell Research & Therapy 2013, 4:23 (28 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Oleg Mirochnitchenko and colleagues discuss the importance and current status of large animal models in the preclinical validation of stem cell-based regenerative therapies, including their advantages and challenges.
		Research Development of fully defined xeno-free culture system for the preparation and propagation of cell therapy-compliant human adipose stem cells Mimmi Patrikoski, Miia Juntunen, Shayne Boucher, Andrew Campbell, Mohan C Vemuri, Bettina Mannerström, Susanna Miettinen Stem Cell Research & Therapy 2013, 4:27 (7 March 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Adipose stem cells cultured in novel xeno-free/serum-free conditions retained their stem cell characteristics, indicating that the culture conditions have potential future use in the development of clinical cell therapies.
		Review Return of results in translational iPS cell research: considerations for donor informed consent Geoffrey P Lomax, Kelly A Shepard Stem Cell Research & Therapy 2013, 4:6 (21 January 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Lomax and Shepherd review the CIRM’s recommendations on informing tissue donors in disease-specific induced pluripotent stem (iPS) cell research, including gaining consent to recontact donors in the event of significant new findings.
		Review US Food and Drug Administration international collaborations for cellular therapy product regulation Judith A Arcidiacono, Joan W Blair, Kimberly A Benton Stem Cell Research & Therapy 2012, 3:38 (28 September 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Judith Arcidiacono and colleagues from the US Food and Drug Administration (FDA) review efforts towards international regulatory convergence for cellular therapy products.
		Review Glia: an emerging target for neurological disease therapy Akshata A Almad, Nicholas J Maragakis Stem Cell Research & Therapy 2012, 3:37 (28 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Almad and Maragakis discuss the role of glial cells in central nervous system diseases and the potential for glial cell replacement in neurological disease therapy.
		Editorial Stem cells and regenerative medicine Mahendra Rao Stem Cell Research & Therapy 2012, 3:27 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Mahendra Rao introduces a new series on clinical applications of stem cells, discussing the progress made in taking stem cells from the bench to the bedside and the challenges remaining.
		Review The Aastrom experience Ronnda L Bartel, Caryn Cramer, Kelly Ledford, Amy Longcore, Christopher Parrish, Theresa Stern, Sharon Watling, Frank Zeigler Stem Cell Research & Therapy 2012, 3:26 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Ronnda Bartel and colleagues describe their experience manufacturing an autologous differentiated cell product for the treatment of critical limb ischemia.
		Review Mesenchymal stem cells for cartilage repair in osteoarthritis Pawan K Gupta, Anjan K Das, Anoop Chullikana, Anish S Majumdar Stem Cell Research & Therapy 2012, 3:25 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The use of bone marrow stromal cells for cartilage repair and their therapeutic potential in osteoarthritis is discussed by Anish Majumdar and colleagues.
		Review Stem cell therapy for the spinal cord Eleanor M Donnelly, Jason Lamanna, Nicholas M Boulis Stem Cell Research & Therapy 2012, 3:24 (9 July 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Nicholas Boulis and colleagues review clinical trials of stem cell transplantation into the spinal cord focusing on motor neuron diseases and spinal cord injury and discuss the optimization of delivery methods.

Explore journal

Articles

Clinical applications of stem cells