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Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells
Tohru Sugawara, Koichiro Nishino, Akihiro Umezawa, Hidenori Akutsu Stem Cell Research & Therapy 2012, 3:8 (8 March 2012)
Abstract | Full text | PDF | PubMed
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Editor’s summary
Hide Akutsu and colleagues review recent research on variation in induced pluripotent stem (iPS) cells, their ability to differentiate and the identity of the differentiated cells.
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Uses of cardiomyocytes generated from induced pluripotent stem cells
Tung-Ying Lu, Lei Yang Stem Cell Research & Therapy 2011, 2:44 (18 November 2011)
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Induced pluripotent stem cells in the study of neurological diseases
Mario A Saporta, Marica Grskovic, John T Dimos Stem Cell Research & Therapy 2011, 2:37 (21 September 2011)
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The role of induced pluripotent stem cells in regenerative medicine: neurodegenerative diseases
Jun Peng, Xianmin Zeng Stem Cell Research & Therapy 2011, 2:32 (28 July 2011)
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Role of Oct4 in maintaining and regaining stem cell pluripotency
Guilai Shi, Ying Jin Stem Cell Research & Therapy 2010, 1:39 (14 December 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Oct4, a transcription factor highly expressed in pluripotent cells and silent in differentiated cells, exerts tight control over pluripotency regulator expression, with further investigation needed surrounding the underlying molecular mechanism.
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Molecular mechanisms of pluripotency and reprogramming
Jie Na, Jordan Plews, Jianliang Li, Patompon Wongtrakoongate, Timo Tuuri, Anis Feki, Peter W Andrews, Christian Unger Stem Cell Research & Therapy 2010, 1:33 (25 October 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Experimental approaches for the generation of induced pluripotent stem cells
Cesar A Sommer, Gustavo Mostoslavsky Stem Cell Research & Therapy 2010, 1:26 (10 August 2010)
Abstract | Full text | PDF | PubMed | Cited on BioMed Central
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Editor’s summary
Sommer and Mostoslavsky summarize current reprogramming methodologies, focusing on the production of genetically unmanipulated induced pluripotent stem (iPS) cells, highlighting important technical details that could influence the biological properties of these cells.
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